Evidence map›Paper›PMID 40447916›Full record

Observational studyGeroScience2026

Development of a multimorbidity health conditions outcome index for caloric restriction interventional studies in older adults: a preliminary investigation in an observational cohort study.

Michael E Miller, Haiying Chen, Mark A Espeland, Fang-Chi Hsu, Denise K Houston, Anne B Newman, W Jack Rejeski, Barbara J Nicklas, Stephen B Kritchevsky

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael E MillerWake Forest University School of Medicine, Winston Salem, NC, USA. mmiller@wakehealth.edu.ORCID 0000-0002-3903-6655
Haiying ChenWake Forest University School of Medicine, Winston Salem, NC, USA.
Mark A EspelandWake Forest University School of Medicine, Winston Salem, NC, USA.
Fang-Chi HsuWake Forest University School of Medicine, Winston Salem, NC, USA.
Denise K HoustonWake Forest University School of Medicine, Winston Salem, NC, USA.
Anne B NewmanSchool of Public Health, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
W Jack RejeskiDepartment of Health and Exercise Sciences, Wake Forest University, Winston Salem, NC, USA.
Barbara J NicklasWake Forest University School of Medicine, Winston Salem, NC, USA.
Stephen B KritchevskyWake Forest University School of Medicine, Winston Salem, NC, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4M
LA-Aging Diversity SupplementU01AG073697 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW, WAGENKNECHT, LYNNE E · 2021 to 2025
$7.1M
The Mobile Devices for Meal Timing (MD4MT) Study: A supplement to HALLO-P using multiple wearable devise to improve accuracy in meal timing for older adults2U01AG073240 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., MILLER, MICHAEL E. · 2021 to 2024
$4.4M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
NIA NIH HHS N01-AG-6-2101NIA NIH HHS N01-AG-6-2103NIA NIH HHS N01-AG-6-2106NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG028050NIA NIH HHS R01-AG028050NIA NIH HHS U01 AG073240NIA NIH HHS U01AG073240NIA NIH HHS U01 AG073697NIA NIH HHS U01AG073697
6 · The paper itself

Abstract

Using multiple sources, we provide the conceptual justification and statistical support for a multimorbidity outcome associated with obesity-related conditions, which we term the Health Conditions Index (HCI). This index was designed to capture the health effects of multi-year studies of caloric restriction for older adults with BMIs in the overweight or obesity classification. We used a subset of participants in the Health, Aging and Body Composition Cohort Study to evaluate multiple aspects of the index and its components over 5 years of follow-up. The 937 participants in the subset had an average age of 73 years and a BMI of 30.7 kg/m

Indexed as

Caloric RestrictionMultimorbidityObesityAgedAged, 80 and overBody Mass IndexCohort StudiesFemaleHumansMaleCaloric restrictionComposite outcomesOlder adults

Identifiers

PMID40447916
PMCPMC12972406

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.