Evidence map›Paper›PMID 40448548›Full record

ReviewFEBS letters2025

Evolutionary interplay between viruses and R-loops.

Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zsolt KarányiMTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Hungary.
Zita KépesDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Hungary.
Zoltán SzabóDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, Hungary.
Eszter CsomaDepartment of Medical Microbiology, Faculty of Medicine, University of Debrecen, Hungary.
Lóránt SzékvölgyiMTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Hungary.ORCID https://orcid.org/0000-0002-7529-0319

Funding

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap NKFIH-K-142137Nemzeti Kutatási Fejlesztési és Innovációs Hivatal TKP2021-EGA-18
6 · The paper itself

Abstract

Viruses frequently interact with host transcriptional and epigenetic regulatory networks. A commonly overlooked element of these interactions is the formation of R-loops, three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single DNA strand. Accumulating evidence implicates R-loops in viral integration site preferences, the regulation of latent viral genomes, epigenetic silencing, and even the genesis of small interfering RNAs (siRNAs) that modulate mobile viral elements. This perspective presents the potential connections among viral genes, transposons, and R-loops; examines the roles of R-loops in viral pathogenesis, latency, and reactivation; explores how viruses harness or evade R-loop-associated responses; and highlights future research directions-from mapping R-loop hotspots to exploiting R-loop modulation for antiviral therapy.

Indexed as

Evolution, MolecularR-Loop StructuresVirusesAnimalsEpigenesis, GeneticGenome, ViralHumanschromatinepigeneticsgene mimicryhost–virus interplayR‐loopRNA–DNA hybridtransposonviral integrationvirus

Identifiers

PMID40448548
PMCPMC12599619

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.