ArticleGeroScience2026
Association between the Planetary Health Diet Index and growth differentiation factor-15: the Seniors ENRICA-2 cohort.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Health and Environmental Impacts, Safety, and Affordability of the EAT-Lancet Planetary Health Diet: A Multidisciplinary Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Protective role of the planetary health diet index against metabolic dysfunction-associated steatotic liver disease: global and individual evidence.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The growth differentiation factor-15 (GDF-15) is an inflammaging biomarker, predictor of cardiovascular disease (CVD), and several other non-communicable diseases (NCD) that represent the main causes of death globally, for which prevention is essential. Current worldwide threats include NCD and environmental burden, where diet is a key determinant. Therefore, the EAT-Lancet Commission developed the Planetary Health Diet Index (PHDI), a dietary pattern designed to ameliorate human and environmental health. The objective of the study was to evaluate the association between the PHDI and serum concentrations of GDF-15 in older adults. Study participants were 2497 people aged + 65 years from the Seniors-ENRICA-2 study. Food consumption was obtained through a validated diet history, and adherence to the PHDI was estimated with a score of 15 food groups (range 0-140), where higher scores indicated better adherence. Analyses for the association between the PHDI and GDF-15 concentrations were performed using multivariable linear regression models, adjusting for main potential confounders. The PHDI showed an inverse dose-response association with GDF-15 concentrations. Compared with participants in the lowest quartile of the PHDI, those in the highest quartile had a mean percentage difference (95% CI) of - 6.8% (- 11.1, - 2.4) in GDF-15 concentrations. The mean percentage difference (95% CI) per 20-point increase of adherence was - 4.4% (- 7.7, - 0.9). Consumption of whole grains, fruits, nuts, and a low intake of trans and saturated fat were important drivers of this association. Results remained robust after adjustment for other inflammation (interleukin 6), renal and cardiac (creatinine, NT-proBNP, cardiac troponin T) biomarkers, and after excluding participants with CVD, type 2 diabetes, and obesity. The PHDI was associated with lower concentrations of GDF-15. Adopting the PHDI may be a useful approach to reduce chronic inflammation and target NCD prevention in the older adult population, while staying within planetary boundaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.