Evidence map›Paper›PMID 40448972›Full record

ReviewThe Journal of physiology2026

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury.

Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M Azarin, Julia C Liu

Abstract readReview
In one paragraph

Review in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Binaphthoquinone attenuates myofibroblast transition of human ventricular cardiac fibroblastsThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. A perspective on the future of heart failure research.Journal of molecular and cellular cardiology plus · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily RozichDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Ulas OzkuredeDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-9058-2168
Shanmugasundaram PakkiriswamiDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.
Ryan GemilereDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.
Samira M AzarinDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA.
Julia C LiuDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-8604-1633

Funding

Modulating mitochondrial calcium in cardiac homeostasis and diseaseR01HL164491 · NHLBI · UNIVERSITY OF MINNESOTA · PI Julia Chang Liu · 2022 to 2026
$2.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL164491NHLBI NIH HHS R01 HL164491
6 · The paper itself

Abstract

Ischaemia-reperfusion injury (IRI) is a major cause of cardiomyocyte damage and death from myocardial infarction. Oxidative stress, dysregulated calcium (Ca

Indexed as

CalciumMitochondria, HeartMitochondrial DynamicsMyocardial Reperfusion InjuryOxidative StressAnimalsHumansMitochondrial Permeability Transition PoreMyocytes, CardiacCalciumMitochondrial Permeability Transition Porecalciumischaemia–reperfusion injurymitochondriamitochondrial dynamicsmyocardial infarctionoxidative stress

Identifiers

PMID40448972
PMCPMC13371218

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.