Evidence map›Paper›PMID 40449992›Full record

ArticleCancer science2025

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC-Dependent Ca

Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaocheng MoDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Jingchuan HeDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Xiaoju ShenDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Changsheng LiDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Xiaoxiang MoDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Kai LiangDepartment of Thoracic Tumor Surgery, The Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Liangjun HeDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Tingting LiDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Xiaoqin PanDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Sisi CaoDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Naiquan MaoDepartment of Thoracic Tumor Surgery, The Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Shangping XingDepartment of Chinese Materia Medica, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Zhiquan ChenDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Zhuo LuoDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Jie YangDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.ORCID https://orcid.org/0000-0002-7968-7022

Funding

Guangxi Medical University Training Program for Distinguished Young ScholarsJoint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation under Grant 2023GXNSFDA026026;2024GXNSFBA010128National Natural Science Foundation of China 82160698;82374093Science and Technology Planning Project of Nanning Qingxiu District 2021013Youth Science Foundation of Guangxi Medical University GXMUYSF202433
6 · The paper itself

Abstract

Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes. Connexin43 (Cx43) is frequently overactivated and positively correlated with tumorigenesis in many cancers, including breast cancer and lung adenocarcinoma, but its role in LUSC remains elusive. In this study, we demonstrated that Cx43 was highly expressed in LUSC tissues as compared to matching normal lung tissues (n = 103) and negatively related to prognosis. Through the 3D spheroid cell invasion assay, zCDX (zebrafish cell line-derived xenograft), and orthotopic lung cancer xenograft model, we further revealed that Cx43 promotes LUSC invasion and migration via forming GJIC. Knockdown of Cx43 reduced the Ca

Indexed as

Carcinoma, Squamous CellConnexin 43Gap JunctionsLung NeoplasmsMAP Kinase Signaling SystemAnimalsCalciumCalcium SignalingCell Line, TumorCell MovementFemaleHumansMaleMiceMiddle AgedNeoplasm InvasivenessCalciumConnexin 43GJA1 protein, humanCa2+/ERK signaling pathwayConnexin43gap junctional intracellular communicationinvasion and metastasislung squamous cell carcinoma

Identifiers

PMID40449992
PMCPMC12317405

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.