Observational studyInternational journal of obesity (2005)2025
Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations.
Observational study in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05798676 (Maternal Characteristics Associated With Child Growth and Adiposity. Search for Nutrigenomic Biomarkers in Peripheral Blood), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Maternal Characteristics Associated With Child Growth and Adiposity. Search for Nutrigenomic Biomarkers in Peripheral Blood
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9 authors.
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Abstract
purposeThe pathways through which milk cortisol affects infant body weight and adiposity remain poorly understood.
aimsTo assess the influence of maternal weight status on maternal cortisol concentrations and infant outcomes; to evaluate the relationship between maternal plasma and milk cortisol concentrations and infant salivary cortisol, body weight and adiposity during the first 3 months of life in a cohort of exclusively breastfed infants; to determine whether milk cortisol mediates these effects; and to explore the association between infant salivary cortisol and measures of body weight and adiposity.
methodsIn this prospective observational study, we measured cortisol concentrations in plasma and milk samples from lactating women at 10 days (n = 68) and 3 months postpartum (n = 34), and in saliva samples from their 3-month-old infants (n = 34). Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol.
resultsPlasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), p = 0.038; 0.95 (0.51, 1.39), p < 0.001], and inversely associated with infant BMI z-score [Beta (95% CI): -0.11 (-0.17, -0.04), p = 0.004; -1.04 (-1.69, -0.39), p = 0.003] at 3 months of lactation, the former mediated by milk cortisol (p = 0.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation.
conclusionOur study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI z-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.
trial registrationThis study was registered at clinicaltrials.gov as NCT05798676.
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