Evidence map›Paper›PMID 40450285›Full record

SynthesisBMC oral health2025

The efficacy of platelet-rich fibrin (PRF) in post-extraction hard and soft tissue healing and associated complications: a systematic review and meta-analysis of split-mouth randomized clinical trials.

Pedram Hajibagheri, Maryam Basirat, Zahra Tabari-Khomeiran, Arash Asadi-Aria

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pedram HajibagheriDental Sciences Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0009-0005-7287-1942
Maryam BasiratDental Sciences Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0003-1671-7279
Zahra Tabari-KhomeiranDepartment of Oral and Maxillofacial Medicine, Student Research Committee, School of Anzali International Campus, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0001-6786-4231
Arash Asadi-AriaDepartment of Oral and Maxillofacial Medicine, Student Research Committee, School of Anzali International Campus, Guilan University of Medical Sciences, Rasht, Iran. Arashasadi3800@gmail.com.ORCID https://orcid.org/0009-0000-3156-5889

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTooth loss is often followed by potential complications, including restricted mouth opening, edema, regional pain, and alveolar osteitis (AO), all of which can impair socket healing and quality of life, compromising the ability to socialize and speak post-extraction. One of the approaches currently used to minimize adverse effects is to use platelet-rich fibrin (PRF) immediately following tooth extraction to reduce these complications. This study aims to evaluate the effectiveness of platelet-rich fibrin in promoting soft and hard tissue healing, and its effects on post-extraction complications.

methodA systematic review and meta-analysis were conducted, following an electronic and manual search of PubMed, EMBASE, Web of Science, and Scopus databases. A total of 455 articles were screened, of which 41 articles underwent systematic review, and 21 studies (701 patients) were included for meta-analysis. Statistical analyses were performed using Comprehensive Meta-Analysis software. The risk of bias was evaluated by three assessors based on five domains. To evaluate PRF effectiveness, the focus was on split-mouth designs to minimize inter-patient variability.

resultPRF significantly improved soft tissue healing (eight studies, p < 0.05), reduced AO incidence (four studies, p < 0.05), and lowered post-operative pain (eleven studies, p < 0.05). However, PRF did not demonstrate statistically significant improvement in bone healing (three studies, p > 0.05).

conclusionThe analysis showed that PRF significantly improved soft tissue healing and reduced the incidence of AO. While PRF helped reduce pain, the results were inconsistent and influenced by the timing of post-operative assessments. The impact on hard tissue healing was controversial, and future research should explore alternative methods to evaluate PRF's effects on bone regeneration.

Indexed as

Platelet-Rich FibrinPostoperative ComplicationsTooth ExtractionWound HealingDry SocketHumansRandomized Controlled Trials as TopicTooth SocketPlatelet-rich fibrinPostoperative complications*/prevention and controlSocket preservationTooth extractionWound healing

Identifiers

PMID40450285
PMCPMC12126912

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.