Evidence map›Paper›PMID 40450604›Full record

ReviewDiscover oncology2025

Research progress on the development and progression of long non-coding RNA in upper gastrointestinal adenocarcinoma.

Haitao Wei, Xiaojin Lin, Ruirui Fang, Sa Zhang, Li Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haitao Wei *Department of Thoracic Surgery, Huaihe Hospital, Henan University, No.8 Bao Bei Street, Gu Lou District, Kaifeng, 475099, Henan, China.
Xiaojin Lin *College of Nursing and Health, Henan University, The north section of Jinming Avenue, Long Ting District, Kaifeng, 475004, Henan, China.
Ruirui FangCollege of Nursing and Health, Henan University, The north section of Jinming Avenue, Long Ting District, Kaifeng, 475004, Henan, China.
Sa ZhangCollege of Nursing and Health, Henan University, The north section of Jinming Avenue, Long Ting District, Kaifeng, 475004, Henan, China.
Li LiDepartment of Thoracic Surgery, Huaihe Hospital, Henan University, No.8 Bao Bei Street, Gu Lou District, Kaifeng, 475099, Henan, China. 10210051@vip.henu.edu.cn.

Funding

2024 Joint Co-construction Project of Medical Science and Technology Tackling Program in Henan Province LHGJ20240411Henan Provincial Department of Education project 25B320018Science and Technology Research Project of Science and Technology Department of Henan Province 252102311053Science and Technology Research Project of Science and Technology Department of Henan Province 252102311055
6 · The paper itself

Abstract

In recent years, the incidence of the upper gastrointestinal adenocarcinoma has risen significantly, but its early symptoms are insidious and its diagnosis lags behind, leading to poor prognosis of patients. Therefore, the exploration of novel biomarkers and precise therapeutic targets has become an urgent clinical problem. lncRNAs, as key molecules in tumour regulation, are involved in the regulation of malignant processes, such as proliferation, metastasis, and apoptosis resistance of tumour cells through epigenetic modification, activation or inhibition of signaling pathways, and other mechanisms. Therefore, lncRNAs can be used as potential biomarkers and therapeutic targets for cancer diagnosis and treatment. The aim of this paper is to systematically study the functional roles of lncRNAs in upper gastrointestinal adenocarcinogenesis and development, to summarize the known effects of lncRNAs on upper gastrointestinal adenocarcinoma, to explore the effects of differential expression of lncRNAs on tumor progression, and to investigate the related signal transduction pathways. Also, the potential of lncRNAs as biomarkers and early diagnostic therapeutic targets will be initially explored. These studies will provide strong theoretical support for the clinical treatment of adenocarcinoma of the upper gastrointestinal tract.

Indexed as

BiomarkersEsophageal adenocarcinomaGastric cardia adenocarcinomaLong non-codingRNASignaling pathwayStomach adenocarcinoma

Identifiers

PMID40450604
PMCPMC12127259

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.