ArticleIntensive care medicine experimental2025
Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy.
Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Automated hemodynamic resuscitation system for computer-controlled norepinephrine, vasopressin, and fluid therapy in endotoxin-induced shock: a feasibility and physiological proof-of-concept study.Intensive care medicine experimental · 2026Article
- Diffuse Correlation Spectroscopy for Noninvasive Monitoring of Peripheral Perfusion During Cardiogenic Shock and VA-ECMO Support: An Experimental Study.Shock (Augusta, Ga.) · 2026Article
- Pressure-dependent coupling between arterial pressure and intercostal muscle blood-flow index during acute hypotension in humans.Experimental physiology · 2026Article
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Authors and funding
12 authors.
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Abstract
backgroundMicrocirculatory dysfunction is a poor prognostic indicator for the management of critically ill patients, highlighting the need for the development of appropriate assessment methods. Current microcirculatory parameters are often indirect, invasive, or lack immediacy and continuity, with no standardised markers for critical care. Diffuse correlation spectroscopy (DCS), a near-infrared optical technique, facilitates the non-invasive real-time monitoring of microvascular dynamics via the blood flow index (BFI). However, the relationship between BFI and conventional microcirculatory parameters in hypovolemic shock remains unclear. This study examined the utility of DCS in assessing the microcirculation during hypovolemic shock in a canine model.
methodsSix male beagle dogs underwent controlled blood withdrawal to induce hypovolemic shock, defined as a ≥ 30% decrease in cardiac output (CO) and mean arterial pressure (MAP) < 60 mmHg or systolic arterial pressure (SAP) < 90 mmHg. BFI was measured using a DCS device attached to the skin of the forelimb. From baseline to blood withdrawals followed by transfusions, changes in BFI were compared with microcirculatory parameters, mixed venous oxygen saturation (S
resultsBlood withdrawal resulted in significant reductions in BFI, CO, and radial artery blood flow, with the corresponding deteriorations in the ΔT, S
conclusionsBlood flow index measured by DCS reflects peripheral perfusion changes and is significantly correlated with clinical parameters during blood withdrawal and transfusion, highlighting its potential for non-invasive, continuous microcirculation monitoring in hypovolemic shock.
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