ArticleClinical pharmacokinetics2025
Utilizing Opportunistic Computed Tomography Imaging to Refine Lean Body Weight Estimates in Patients with Obesity.
Article in Clinical pharmacokinetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionWhile dual-energy X-ray absorptiometry (DEXA) is the gold standard for measuring lean body weight (LBW), computed tomography (CT) provides muscle composition and distribution metrics that can refine LBW for better weight-based dosing. We explored how existing computed tomography (CT) images could be utilized to better estimate LBW.
methodsSixty-three adult patients (71.4% female) with a median age of 53.4 years and mean BMI of 36.84 having both DEXA and CT scans were retrospectively analyzed to assess the relationship between CT-based skeletal muscle variables and DEXA-derived LBW.
resultsLinear regression results revealed significant correlations. CT-derived skeletal muscle area (SMA) strongly predicted DEXA-derived LBW (p value < 0.05 and R DISCUSSIONS/
conclusionThis study demonstrates opportunistic CT scan data may improve an existing equation for LBW that has been predictive of select drug pharmacokinetic parameters. Improving LBW estimation may enable improved personalized drug dosing strategies in patients with obesity and other populations that benefit from using LBW over total body weight.
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