ReviewComprehensive Physiology2025
Adipose Tissue-Derived Adipokines in Vascular Physiology and Pathophysiology: Insights and Implications.
Review in Comprehensive Physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- ITIH5 drives adipocyte differentiation and obesity-associated metabolic dysregulation via PI3K/AKT signaling activation.Journal of molecular cell biology · 2026Article
- Effects of Chlorogenic Acid on Cellular Senescence in an In Vitro Model of 3T3-L1 Murine Adipocytes.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Adipose tissue serves not only as a storage organ but also plays an active role in maintaining the body's homeostasis as an endocrine component. Mainly made up of adipocytes that store energy as triglyceride droplets, this tissue also contains fibroblasts, immune cells, neuronal cells, and endothelial cells. Collectively, these non-adipocyte cells are known as the stromal vascular fraction. Evidence suggests that both the quantity and quality of adipose tissue are crucial in regulating vascular physiology by influencing lipid metabolism and secreting important signaling molecules called adipokines. This review aims to systematically explore the complex effects of adipose tissue on vascular regulation with a particular focus on two well-characterized adipokines-leptin and adiponectin-whose receptors are abundantly expressed in the vasculature. We further aim to provide an overview of both classical and recent research to emphasize the significance of the interplay between adipose tissue and vascular biology.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.