ArticleScientific reports2025
Epidemiological and demographic analysis of liver cancer attributable to modifiable risk factors from 1990 to 2021.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Article
- Methylation-mediated regulation of tumor-suppressor function of the miR-379/656 (C14MC) cluster and its clinical utility in hepatocellular carcinoma.BMC cancer · 2026Article
- Global, regional, and national burden of liver cancer attributable to hepatitis B virus among middle-aged and older adults from 1990 to 2021 and projections to 2035: results of the Global Burden of Disease Study 2021.Journal of gastrointestinal oncology · 2025Article
- Temporal trends in cancer mortality attributable to high BMI in Asia: an age-period-cohort analysis based on GBD 1992-2021.Frontiers in endocrinology · 2025Article
- Study on the disease burden of lip and oral cancer attributable to tobacco use: based on the 2021 Global Burden of Disease study.Frontiers in oncology · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cancer is a leading cause of cancer mortality globally, with high Body Mass Index (BMI), alcohol consumption, and smoking identified as major modifiable risk factors. This study assessed global trends in liver cancer mortality attributable to these factors from 1990 to 2021, using data from the 2021 Global Burden of Disease Study. Mortality and Disability-Adjusted Life Years (DALYs) attributable to liver cancer were analyzed by gender, age, and Socio-Demographic Index (SDI) region. The age-standardized mortality rates (ASMRs) for liver cancer attributable to smoking showed a decreasing trend (EAPC: - 0.844 (- 0.961, - 0.727)), while ASMRs for liver cancer attributable to high BMI increased across all age groups, especially in high-SDI regions. Age-Period-Cohort (APC) modeling indicated that the liver cancer burden attributable to high BMI rose sharply in recent years, with projections suggesting global DALYs for liver cancer attributable to high BMI will reach 145,100 by 2050, predominantly affecting males. A visualization platform for these results is available at http://116.196.73.86:3838/GBD-LiverCancer/ . These findings highlight the urgent need for targeted health policies to mitigate the impact of high BMI on liver cancer, particularly through obesity prevention efforts in high-SDI regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.