Evidence mapPaperPMID 40451925Full record

ArticleExperimental & molecular medicine2025

Oncogenic function of growth arrest-specific transcript 5 by competing with miR-423-3p to regulate SMARCA4 in hepatocellular carcinoma.

Sang Yean Kim, Jin Woong Ha, Min Jeong Na, Soyoung Jeon, Jung Hwan Yoon, Won Sang Park, Suk Woo Nam

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Plasma expression of long non-coding RNAFrontiers in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sang Yean Kim *Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.
Jin Woong Ha *Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.
Min Jeong NaDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.
Soyoung JeonDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.
Jung Hwan YoonDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-7770-2965
Won Sang ParkDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-9090-0584
Suk Woo NamDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea. swnam@catholic.ac.kr.

Funding

National Research Foundation of Korea (NRF) NRF-2022R1A2C1091808
6 · The paper itself

Abstract

Long noncoding RNA growth arrest-specific transcript 5 (GAS5) has been identified as a tumor suppressor due to its downregulation in several cancers. However, our comprehensive analyses revealed aberrant overexpression of GAS5 in various cancers, with a direct association with SMARCA4 in hepatocellular carcinoma (HCC). Differential expression analyses were conducted using publicly available transcriptome datasets. Functional studies of GAS5 and its downstream targets in HCC were performed via small interfering RNA-mediated knockdown in various HCC cell lines, in vivo xenograft mouse models and spontaneous liver cancer models in Ras-transgenic mice. Here we discover that METTL3-mediated N

Indexed as

Carcinoma, HepatocellularDNA HelicasesGene Expression Regulation, NeoplasticLiver NeoplasmsMicroRNAsNuclear ProteinsRNA, Long NoncodingTranscription FactorsAdenosineAnimalsCarcinogenesisCell Line, TumorCell ProliferationHumansMethyltransferasesMiceAdenosineDNA HelicasesGAS5 long non-coding RNA, humanIGF2BP2 protein, humanMethyltransferasesMETTL3 protein, humanMicroRNAsN-methyladenosineNuclear ProteinsRNA-Binding ProteinsRNA, Long NoncodingSMARCA4 protein, humanTranscription Factors

Identifiers

PMID40451925
PMCPMC12229648

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.