Evidence map›Paper›PMID 40452002›Full record

ReviewPhysiological reports2025

Adiponectin and gastric fundus: A potential target for gut-brain axis dysfunctions.

R Garella, F Palmieri, F Chellini, L Tarchi, V Ricca, G Castellini, C Sassoli, R Squecco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

R GarellaDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-3194-7603
F PalmieriDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy.
F ChelliniDepartment of Experimental and Clinical Medicine, Section of Anatomy and Histology, Imaging Platform, University of Florence, Florence, Italy.
L TarchiDepartment of Health Sciences, Psychiatry Unit, University of Florence, Florence, Italy.
V RiccaDepartment of Health Sciences, Psychiatry Unit, University of Florence, Florence, Italy.
G CastelliniDepartment of Health Sciences, Psychiatry Unit, University of Florence, Florence, Italy.
C SassoliDepartment of Experimental and Clinical Medicine, Section of Anatomy and Histology, Imaging Platform, University of Florence, Florence, Italy.
R SqueccoDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin (ADPN) is a pleiotropic hormone produced by adipose tissue involved in the control of body weight, energy expenditure, and feeding behaviors. Alongside a central effect, ADPN acts on peripheral organs such as the stomach, where it can favor gastric fundus relaxation, reinforcing central satiety signals. Notably, ADPN serum levels are dysregulated in several conditions affecting the gastrointestinal tract. Moreover, altered hormone levels coexist with disorders related to the gut-brain axis malfunctioning, that is, eating disorders and inflammatory bowel diseases. Aiming at considering the effective utility of ADPN in a wide range of clinical conditions, there is an urgent need to identify its targets, clarify its mechanism of action, and downstream effectors. In this view, the present review highlights the advancement in elucidating ADPN effects on gastric fundus, describing its ability to cause morphofunctional alterations of smooth muscle cells, affecting their excitability, contractile machinery, and motor response. This comprehensive overview also provides a critical appraisal on the potential translational applications, including the possibility to consider ADPN as a biomarker for the diagnosis and staging of different clinical conditions. Finally, this review explores the potential employment of ADPN analogues for treating disorders characterized by functional gastric disturbances or altered feeding behaviors.

Indexed as

AdiponectinBrainBrain-Gut AxisGastric FundusAnimalsHumansAdiponectinadiponectinappetiteeating disordersgastric smooth muscleinflammatory bowel disease (IBD)obesity

Identifiers

PMID40452002
PMCPMC12127117

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.