Evidence map›Paper›PMID 40452069›Full record

Trial reportThe British journal of nutrition2025

Effect of supplementation with vitamin D on biochemical markers of iron status and erythropoiesis in older people: BEST-D trial.

Abigail A Lamikanra, Hoi Pat Tsang, Alireza Morovat, Harold Hin, Jonathan Emberson, Michael Hill, Robert Clarke, Jane Armitage, David J Roberts

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abigail A LamikanraNHS Blood and Transplant, Oxford, UK.ORCID https://orcid.org/0000-0002-9287-2177
Hoi Pat TsangNHS Blood and Transplant, Oxford, UK.
Alireza MorovatDepartment of Clinical Biochemistry, Oxford University Hospital Trust, Oxford, UK.
Harold HinHightown Surgery, Banbury, Oxfordshire, UK.
Jonathan EmbersonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Michael HillClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-9802-8241
Jane ArmitageClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
David J RobertsNHS Blood and Transplant, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous observational studies suggested that vitamin D may control the absorption of iron (Fe) by inhibition of hepcidin, but the causal relevance of these associations is uncertain. Using placebo-controlled randomisation, we assessed the effects of supplementation with vitamin D on biochemical markers of Fe status and erythropoiesis in community-dwelling older people living in the UK. The BEST-D trial, designed to establish the optimum dose of vitamin D3 for future trials, had 305 participants, aged 65 years or older, randomly allocated to 4000 IU vitamin D3 (

Indexed as

CholecalciferolDietary SupplementsErythropoiesisIronVitamin DAgedAged, 80 and overBiomarkersDouble-Blind MethodFemaleFerritinsHepcidinsHumansMaleReceptors, TransferrinTransferrinBiomarkersCholecalciferolFerritinsHepcidinsIronReceptors, TransferrinTransferrinVitamin DErythropoiesisHealthy older populationIronRandomised Controlled TrialVitamin D supplementation

Identifiers

PMID40452069
PMCPMC12379118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.