ReviewMedicinal research reviews2025
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy.
Review in Medicinal research reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Dysregulation of human ClpP using small molecules with piperazine-based scaffold for diffuse intrinsic pontine glioma therapy validated by patient-derived tumor organoids.Research square · 2026Article
- Mitochondrial Protease ClpP: Cancer Marker and Drug Target.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Can Focused Ultrasound Overcome the Failure of Chemotherapy in Treating Pediatric Diffuse Intrinsic Pontine Glioma Due to a Blood-Brain Barrier Obstacle?Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Pediatric Diffuse Midline Glioma H3K27-Altered: From Developmental Origins to Therapeutic Challenges.Cancers · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient survival. Many cancer-based studies have investigated gene expression patterns and gene signatures associated with radiotherapy. However, such studies are scarce in the field of pediatric cerebral tumors. Moreover, no studies have been conducted on the changes in gene expression profiles "before and after radiotherapy treatment in pediatric cerebral tumors," especially in diffuse intrinsic pediatric glioma, actually classified as diffuse midline glioma. This review aims to explore the expression of gene profiles in cerebral tumors before and after radiotherapy, unraveling the molecular mechanisms underlying treatment response and potential biomarkers for prognosis and therapeutic targeting. By examining the current literature (years 2011-2023), we provide an overview of the present understanding of the gene expression changes associated with radiotherapy in intrinsic brain tumors. Insights from these studies suggest alterations in key signaling pathways, DNA repair mechanisms, and cell cycle regulation in response to radiotherapy. Our analysis highlighted potential genomic targets and the importance of identifying key genes and pathways involved in these responses to develop personalized treatment strategies and improve patient outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.