Evidence map›Paper›PMID 40452297›Full record

ArticleProteins2025

Probing Enzymatic Acetylation Events in Real Time With NMR Spectroscopy: Insights Into Acyl-Cofactor Dependent p300 Modification of Histone H4.

Sophia M Dewing, Scott A Showalter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sophia M DewingCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0001-7744-4177
Scott A ShowalterCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0001-5179-032X

Funding

Computation, Bioinformatics, and Statistics (CBIOS) Training ProgramT32GM102057 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHIAROMONTE, FRANCESCA, GIRIRAJAN, SANTHOSH · 2013 to 2022
$2.7M
Acetyllysine Structure-Function Analysis by 13C Direct-Detect NMR SpectroscopyR21GM137129 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SHOWALTER, SCOTT A · 2020 to 2021
$416k
NIGMS NIH HHS R21 GM137129NIGMS NIH HHS T32 GM102057NIH HHS R21-GM137129NIH HHS T32GM102057
6 · The paper itself

Abstract

Lysine acylation is a rapidly expanding class of post-translational modifications with largely unexplored functional roles; the study of acylations beyond acetylation is especially impeded by limited methods for their preparation, detection, and characterization in vitro. We previously reported a nuclear magnetic resonance (NMR)-based approach to monitor Nε-lysine acetylation following Ada2/Gcn5-catalyzed installation of a

Indexed as

Histonesp300-CBP Transcription FactorsAcetylationAcylationCarbon IsotopesHumansKineticsLysineNuclear Magnetic Resonance, BiomolecularProtein Processing, Post-TranslationalCarbon IsotopesHistonesLysinep300-CBP Transcription Factorsacetylationacylationhistone H4nuclear magnetic resonancep300‐CBP proteinpropionylation

Identifiers

PMID40452297
PMCPMC12354013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.