ArticleFrontiers in immunology2025
Correlation between severe acute respiratory syndrome coronavirus 2 infection and serum anti-neutrophil cytoplasmic antibody formation.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of autoantibody responses in COVID-19 patients: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the impact of SARS-CoV-2 infection on the formation of antineutrophil cytoplasmic antibodies (ANCA). Methods: Serum samples from 154 patients infected with SARS-CoV-2 were collected and tested for ANCA and antinuclear antibodies (ANA) using indirect immunofluorescence assay (IFA). Enzyme-linked immunosorbent assay (ELISA) was used to confirm the target antigens in ANCA fluorescence-positive samples. Eighty-seven healthy individuals were selected as the control group. Statistical analysis was performed using SPSS 26.0 software, with P < 0.05 considered statistically significant. Results: The ANCA fluorescence positivity rate in the control group (1.1%) was not significantly different from that in COVID-19 positive patients (2.5%) (χ² = 0.574, P > 0.05). Among COVID-19 positive patients, 4 cases (2.5%) were ANCA fluorescence positive, while 10 cases (6.4%) were ANA positive. The difference between these two rates was not statistically significant (χ² = 2.694, P > 0.05). Conclusion: The Omicron variant of SARS-CoV-2 has minimal association with the formation of serum ANCA.
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