Evidence map›Paper›PMID 40453720›Full record

ArticleFrontiers in nutrition2025

Association between serum and red blood cell folate concentrations and urinary phthalate metabolite concentrations in US adults: evidence from a large population-based study.

Xiaojing Huang, Huan Zhang, Yaoyu Luo, Chenhui Yang, Jue Huang, Ting Zhou, Junfeng Qi, Junlin Li, Shuzhen Zhu, Yaqin Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojing HuangDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
Huan ZhangDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
Yaoyu LuoState Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan); Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chenhui YangInstitute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jue HuangDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
Ting ZhouDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
Junfeng QiHubei Center for Disease Control and Prevention, Wuhan, China.
Junlin LiHubei Center for Disease Control and Prevention, Wuhan, China.
Shuzhen ZhuHubei Center for Disease Control and Prevention, Wuhan, China.
Yaqin ZhangGeriatric Hospital Affiliated with Wuhan University of Science and Technology, Wuhan, China.
Ling ZhangDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
Xiaojie SunDepartment of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have suggested that folate may mitigate the impact of exposure to environmental chemicals. We aimed to explore the relationship between blood folate biomarker concentrations and urine phthalate metabolites. Methods: Based on data from the National Health and Nutrition Examination Survey spanning 2005 to 2016, 8,218 participants with measurements of folate biomarkers in blood and phthalates exposure in urine were included. Survey Results: After adjusting for covariates, each unit increase in the natural logarithm-transformed serum folate concentration was associated with significant reductions of 7.41% in MEHP and 7.10% in MEHHP. After further adjustment for HEI-2020, these inverse associations strengthened to 8.11% (95% CI: -13.18, -2.76%) for MEHP and 8.07% (95% CI: -14.20, -1.52%) for MEHHP. Quartile analysis revealed that participants in the highest serum folate quartile exhibited significantly lower levels of MEHP, MEOHP, MECPP, and MEHHP compared to those in the lowest quartile (all Conclusion: These findings indicate that folate is associated with reduced concentrations of phthalate metabolites in urine, which may hold significant relevance for the utilization of folate as a strategy to reduce the accumulation of phthalate burden.

Indexed as

biomarkersexposurefolic acidNHANESphthalates

Identifiers

PMID40453720
PMCPMC12122348

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.