Evidence map›Paper›PMID 40453883›Full record

ReviewOpen forum infectious diseases2025

Multidisciplinary Guidance to Care for Persons With Xylazine-Associated Wounds.

Wei-Teng Yang, Jessica A Meisner, Christina Maguire, Kelly E Dyer, Rachel McFadden, Ashish P Thakrar, Drew T Dickinson, Deanna Berg, Ave Preston, Michael Z David and 3 more

Abstract readReview
In one paragraph

Review in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei-Teng YangDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0006-3605-8724
Jessica A MeisnerDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Christina MaguireDepartment of Pharmacy, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5590-2736
Kelly E DyerDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Rachel McFaddenPrevention Point Philadelphia, Philadelphia, Pennsylvania, USA.
Ashish P ThakrarCenter for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Drew T DickinsonDepartment of Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-8018-4070
Deanna BergDepartment of Pharmacy, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, USA.
Ave PrestonDepartment of Wound and Ostomy Nursing, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michael Z DavidDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1926-7800
Jeanmarie PerroneCenter for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Naasha TalatiDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kathleen O DegnanDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xylazine, an adulterant of unregulated opioid supplies, is increasingly prevalent in the United States and associated with distinctive wounds. Xylazine-associated wounds (XAWs) are primarily noted in the extremities and are not always associated with injection drug use. XAWs are often chronic and can become superinfected, posing a great challenge to clinical care. We share multidisciplinary guidance to care for persons with XAWs: (1) substance use disorder treatment and longitudinal multidisciplinary care including addiction medicine, wound care, infectious diseases, and surgery are imperative; (2) avoid aggressive debridement; (3) administer empirical antibiotics for methicillin-resistant

Indexed as

illicitly manufactured fentanylmultidisciplinary careopioid use disorderpersons who use drugsxylazine-associated wounds

Identifiers

PMID40453883
PMCPMC12125673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.