Evidence mapPaperPMID 40454002Full record

ReviewNPJ cardiovascular health2025

Mechanisms and implications of vascular-homing CD8 T cells in atherosclerosis.

Xi Su, Katelyn A O'Hare, Michael L Freeman

Abstract readReview
In one paragraph

Review in NPJ cardiovascular health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CD8Nature reviews. Cardiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xi SuRustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH USA.
Katelyn A O'HareRustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH USA.
Michael L FreemanRustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH USA.

Funding

NIAID NIH HHS R21 AI162150NIAID NIH HHS R21 AI167675
6 · The paper itself

Abstract

CD8 T cells likely contribute to atherosclerosis. Here, we review the relationship of vascular-homing CD8 T cells to atherosclerotic cardiovascular disease, with discussions of atherogenic and atheroprotective CD8 T cell subsets, encompassing their origin, activation, antigen-specificity, trafficking, and functionality. Furthermore, we explore factors that promote CD8 T cell vascular-homing phenotypes, such as infections and inflammation, and describe innovative therapeutic strategies targeting vascular-homing CD8 T cells in people with atherosclerosis.

Indexed as

AtherosclerosisImmunology

Identifiers

PMID40454002
PMCPMC12119338

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.