Evidence map›Paper›PMID 40454101›Full record

ArticleiScience2025

A bio-instructive, bioactive

Ayesha Aijaz, Margarita Elloso, Yufei Chen, Faraz Chogan, Bhavishya Challagundla, Graham Rix, Supriya Hota, Anna Matveev, Marc G Jeschke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ayesha AijazDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Margarita EllosoDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Yufei ChenDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Faraz ChoganHamilton Health Sciences, Center for Burn Research, Hamilton, ON, Canada.
Bhavishya ChallagundlaHamilton Health Sciences, Center for Burn Research, Hamilton, ON, Canada.
Graham RixHamilton Health Sciences, Center for Burn Research, Hamilton, ON, Canada.
Supriya HotaSunnybrook Research Institute, Toronto, ON, Canada.
Anna MatveevHamilton Health Sciences, Center for Burn Research, Hamilton, ON, Canada.
Marc G JeschkeDepartment of Surgery, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early initiation of wound regeneration and healing is the primary determinant of survival for burn patients. While superficial burns do not require secondary interventions and undergo spontaneous healing, full-thickness burns exceed the intrinsic capacity of body to induce skin regeneration. Herein, we developed a wound matrix system, referred to as PEGScarX that provides critical bioactive and bio-instructive cues to modulate cell fate decisions for burn wound healing. Our results indicate that PEGScarX promotes faster wound healing kinetics and reduces scar formation in burn wounds. PEGScarX induces fibroblast and epidermal stem cell repopulation, inhibits transdifferentiation of fibroblasts to myofibroblasts, and induces a pro-regenerative immune cell niche. These findings unravel an opportunity to reduce morbidity and mortality in burn patients due to inadequate wound regeneration and reduce the occurrence of pathological scaring.

Indexed as

BiomaterialsCell biologyPolymers

Identifiers

PMID40454101
PMCPMC12124673

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.