Evidence map›Paper›PMID 40454169›Full record

ReviewFrontiers in veterinary science2025

Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners.

Aline Yen Ling Wang, Ana Elena Aviña, Yen-Yu Liu, Huang-Kai Kao

Abstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aline Yen Ling WangCenter for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ana Elena AviñaCenter for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yen-Yu LiuCenter for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Huang-Kai KaoDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment. In this review, we discuss the multi-factorial advantage of SVF cited as anti-inflammatory, regenerative, and angiogenic, all of which improve the complex pathology of OA. The heterogeneous cellular structure of SVF allows it to achieve joint improvement through both cell-based tissue restoration and signaling functions that benefit joint health. Veterinary practitioners need to consider essential aspects for clinical practice including patient selection criteria together with specific dosage recommendations along with additional therapies like platelet-rich plasma. Existing clinical data shows that SVF reduces pain while helping restore joint functions while practitioners face challenges when standardizing protocols and evaluating long-term safety aspects. Future research initiatives aim to translate advanced technologies including bioactive scaffolds, gene editing, and artificial intelligence which show promise for enhancing therapeutic results. This review integrates existing information about SVF while enlightening veterinarians about the gap areas to assist them make informed decisions when implementing SVF in practice. SVF represents a huge step forward in veterinary regenerative medicine because it enables better management of OA as well as other orthopedic applications.

Indexed as

canine osteoarthritisinflammation modulationregenerative medicinestromal vascular fractionSVFveterinary orthopedics

Identifiers

PMID40454169
PMCPMC12122444

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.