ReviewFrontiers in neuroscience2025
Unlocking nerve regeneration: electrical stimulation and bioscaffolds to enhance peripheral nerve regeneration.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Article
- Where Do We Stand for Nerve Regeneration and Functional Recovery After Vascularized Composite Allotransplantation?Microsurgery · 2026Review
- Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value.International journal of molecular sciences · 2025Review
- Multifunctional nanoplatforms for optic nerve regeneration integrating anti-inflammatory, epigenetic, and ionic mechanisms with emerging artificial intelligence technologies.Cell biology and toxicology · 2025Review
- Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration.NPJ Regenerative medicine · 2025Review
- HMGB1-Induced Neurite Outgrowth in the Dorsal Root Ganglion Neurons and Regeneration Priming after their Axonal Injury by Sciatic Nerve Crush.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Advanced biomaterials and virtual reality for interventions in rare episodic cluster headache mimicking SUNCT syndrome: emerging directions in precision pain management.Annals of medicine and surgery (2012) · 2025Article
- CRISPR and Artificial Intelligence in Neuroregeneration: Closed-Loop Strategies for Precision Medicine, Spinal Cord Repair, and Adaptive Neuro-Oncology.International journal of molecular sciences · 2025Review
- Biphasic Electrical Stimulation of Schwann Cells on Conducting Polymer-Coated Carbon Microfibers.International journal of molecular sciences · 2025Article
- Peripheral Nerve Regeneration Reimagined: Cutting-Edge Biomaterials and Biotechnological Innovations.Bioengineering (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injury (PNI) is a challenging clinical problem resulting in disabling sensorimotor deficits, which may become permanent if recovery does not take place in a timely manner. In this review, we examine recent insights into key molecular mechanisms-particularly MAPK/ERK and PI3K/Akt-that govern Wallerian degeneration, Schwann cell (SC) reprogramming, and macrophage polarization. These and other critical steps in the axonal regeneration process must be understood and navigated for a therapeutic approach to be successful. We highlight emerging therapeutic strategies, such as electrical stimulation (ES), which appears to work by activating many of these pro-regenerative gene networks, both in neurons and non-neuronal support cells. Advances in biomaterial engineering, including natural and synthetic scaffolds enriched with growth factors, also show promise in facilitating axonal regeneration across nerve gaps. We postulate that integrating optimized ES protocols with innovative scaffold designs will allow for synergies to further enhance axonal regeneration and functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.