ArticleClinical cardiology2025
C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index as an Independent Risk Factor for Postoperative Atrial Fibrillation Recurrence.
Article in Clinical cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Preprocedural CALLY Index As a Novel Predictor of Pacemaker Requirement After Transcatheter Aortic Valve Replacement.CJC open · 2026Article
- Association Between the CALLY Index and Carotid Artery Stenosis Severity in Patients Younger and Older than 65 Years.Journal of clinical medicine · 2026Article
- C-reactive protein-albumin-lymphocyte index and atrial fibrillation recurrence after radiofrequency ablation in heart failure.iScience · 2025Article
- How to Demonstrate the Association Between the Inflammation and Atrial Fibrillation Recurrence.Clinical cardiology · 2025Article
- Response by Deng et al. Regarding Article, "C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index as an Independent Risk Factor for Postoperative Atrial Fibrillation Recurrence".Clinical cardiology · 2025Article
- Age-stratified selection of albumin-based inflammatory ratios: a novel strategy for optimizing risk prediction of severe pneumonia in children.Frontiers in pediatrics · 2025Article
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14 authors.
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Abstract
backgroundAtrial fibrillation (AF) recurrence after catheter ablation remains a clinical challenge despite guideline-recommended efficacy. Emerging evidence implicates inflammatory biomarkers in predicting arrhythmia recurrence. This study investigated the novel CALLY index, a composite inflammatory marker, as a prognostic indicator for postablation AF recurrence.
methodsIn this prospective cohort study, 556 consecutive AF patients undergoing catheter ablation (June 2018-June 2023) were stratified into recurrence and sinus rhythm (SR) maintenance groups. Cox regression and Kaplan-Meier analyses evaluated associations between the CALLY index and recurrence risk. Predictive accuracy was assessed via receiver operating characteristic (ROC) curves and area under the curve (AUC).
resultsOver a median 12-month follow-up, 102 patients (18.3%) experienced recurrence. The SR group exhibited significantly higher CALLY indices than the recurrence group (3.24 ± 1.68 vs. 1.89 ± 0.57; p < 0.001). Univariate Cox regression identified the CALLY index as inversely associated with recurrence (HR: 0.439, 95% CI: 0.292-0.659; p < 0.001), with persistence after multivariable adjustment (HR: 0.887, 95% CI: 0.789-0.956; p = 0.031). Tertile-based stratification revealed a 29% lower recurrence risk in the high-CALLY group versus the low-CALLY group (HR: 0.71, 95% CI: 0.68-0.76; p = 0.017). ROC analysis demonstrated optimal discrimination at a CALLY threshold ≥ 1.433 (AUC: 0.7899; sensitivity: 76.4%; specificity: 74.8%; p < 0.001).
conclusionThe CALLY index independently predicts AF recurrence postablation, offering potential utility in risk stratification. These findings support its integration into clinical decision-making to optimize post-procedural management.
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