ArticleAnatolian journal of cardiology2025
Deep Dive into the Cardio-Pulmonary-Renal Interactions in Patients with Pulmonary Hypertension: Serum Creatinine Levels Even Within the Normal Range Related to Long-Term Survival.
Article in Anatolian journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal function in patients with pulmonary hypertension (PH) can be disrupted due to hypotension, low cardiac output, and venous pressure overload because of the its dependency on the pressure gradient between systemic arterial and venous circulations. The aim was to investigate whether measures of venous and pulmonary circulations determine renal function in patients with PH.
methodsThe single-center study group comprised 1071 patients with a hemodynamically confirmed PH diagnosis. Serum creatinine level was used for surrogate of renal perfusion status. Echocardiographic measures included left ventricle ejection fraction (LVEF), tricuspid annular plane excursion (TAPSE), and right atrial area (RAA). Hemodynamic parameters included mean aortic and pulmonary pressures (MAP and PAMP), pulmonary capillary wedge (PCWP) and right atrial pressure (RAP), transsystemic and transpulmonary pressure gradients (TSG and TPG), and pulmonary and systemic vascular resistances (PVR and SVR), respectively.
resultsSerum creatinine was significantly associated with TSG, RAP, TPG, PAMP, PVR, PVR/SVR ratio, cardiac index, stroke volume index, mixed venous O2 Sat %, TAPSE, RAA, LVEF%, pericardial effusion and BNP/NT-ProBNP levels (P < .05 for all), but not with MAP, PCWP, and SVR. According to the creatinine tertiles, survival rates were significantly different between groups 1 vs. 3, and 2 vs. 3 (P = .001 for both).
conclusionAn integrative approach regarding cardio-pulmonary-renal interactions seems to provide a comprehensive perspective for circulatory status and renal function in patients with PH and congestive heart failure. More importantly, even small increases of serum creatinine levels within the normal range seems to be associated long-term survival differences.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.