Observational studyInvestigative ophthalmology & visual science2025
Posterior Retinal Ischemia Correlates With Vision in Patients With Diabetes.
Observational study in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Baseline Deep Capillary Plexus Ischemia Predicts Earlier Diabetic Retinopathy Complications Than Foveal Avascular Enlargement.American journal of ophthalmology · 2026Article
- Edaravone Attenuates Retinal Ganglion Cell Ferroptosis Induced by Ischemia Reperfusion via Inhibiting the p38 MAPK/ATF3 Signaling Pathway.Molecular neurobiology · 2026Article
- Validation of Deep Capillary Plexus OCTA Metrics as Predictors of Diabetic Retinopathy Complications: A One-Year Longitudinal Study.Research square · 2026Article
- Retinal Ischemic Perivascular Lesions Screen for Vision-Threatening Diabetic Retinopathy Visualized on Ultra-Widefield Fluorescein Angiography.Translational vision science & technology · 2026Article
- Macular Microaneurysms Are Associated With Chronic Kidney Disease and Deep Capillary Plexus Ischemia in Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Macular Deep Capillary Plexus Ischemia as a Biomarker for Identifying Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Understanding How Low Luminance Visual Deficit Progresses With Advancing Diabetic Macular Ischemia and Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- The Importance of Matching Optical Coherence Tomography Angiography Metrics to Diabetic Retinopathy Severity for Detecting Progression.Investigative ophthalmology & visual science · 2025Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Purpose: The purpose of this study was to investigate whether the topographic location of retinal non-perfusion influences visual function, specifically low luminance visual acuity (LLVA) and best-corrected visual acuity (BCVA), in individuals with diabetes. Methods: In this cross-sectional observational study, individuals with diabetes across the spectrum of diabetic retinopathy (DR) severity were enrolled. LLVA and BCVA were measured according to the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol, with a 2.0-log unit neutral density filter for LLVA. Retinal ischemia was evaluated using ultra-widefield fluorescein angiography (UWF-FA) to manually quantify non-perfusion within (posterior ischemia) and outside (peripheral ischemia) the ETDRS seven fields. Macular ischemia was assessed by optical coherence tomography angiography (OCTA) using geometric perfusion deficits (GPDs) in both the superficial and deep capillary plexus (DCP). Associations between visual acuity and various explanatory variables, focusing on retinal ischemic parameters were assessed with linear mixed models. Results: A total of 181 eyes from 126 patients without diabetic macular edema were analyzed. Increasing DR severity reduced both BCVA and LLVA. After adjusting other explanatory variables, age and posterior ischemia (estimate = -0.46, P = 0.046) were significant for LLVA. In contrast, age, sex, posterior ischemia (estimate = -0.50, P = 0.009), and GPD-DCP (estimate = -0.25, P = 0.049) were statistically significant for BCVA. Conclusions: Retinal ischemia's topographic location differentially affects visual function in diabetes. Posterior ischemia predominantly impacts LLVA, whereas both macular and posterior ischemia contribute to BCVA decline. These results highlight the importance of assessing retinal ischemia beyond the macula to better understand visual function deficits in patients with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.