SynthesisNaunyn-Schmiedeberg's archives of pharmacology2025
The effect of flavonoids on the doxorubicin efficacy in cancer treatment.
Synthesis in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death.Medical oncology (Northwood, London, England) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although doxorubicin (DOX) chemotherapy is widely used to treat malignant tumors, its cardiotoxicity restricts its widespread use. Flavonoids may mitigate DOX-induced cardiotoxicity. A systematic review was conducted to determine whether flavonoids can prevent DOX-induced cardiotoxicity. Therefore, it would be interesting to examine the effects of flavonoids on DOX activity. Based on a Boolean query in the well-known Scopus database, we present our review of doxorubicin and flavonoids simultaneously as combination drugs for cancer treatment. Following the retrieval and review of the intended investigations based on the input keywords, the anticancer mechanisms of flavonoids and doxorubicin are discussed, along with their effects on different targets. Several apoptotic/pro-apoptotic proteins are induced through targeted signaling pathways, which may activate several caspases that cause apoptosis, leading to cell death. In this study, flavonoids differentially modulated the efficacy of doxorubicin chemotherapeutics by interfering with chemotherapy-induced apoptosis and cell cycle arrest. Based on this information, we were able to better understand how dietary agents may affect chemotherapy.
Indexed as
Identifiers
40455233What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.