ArticleJournal of molecular histology2025
Significance feature of saffron on testicular histomorphometry and expression profile of antioxidant enzymes in mice with induced multiple sclerosis: an in-vivo study.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The interplay between inflammation and oxidative stress in depression: pathogenic mechanisms and treatment approaches.Molecular biology reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS), a chronic autoimmune disease of the central nervous system (CNS), is characterized by demyelination and oxidative stress. Given the established link between MS and impaired reproductive function, the potential protective role of Crocus sativus (saffron) against testicular damage warrants investigation. This study aimed to assess the effects of saffron on testicular histomorphology and the expression of antioxidant enzymes in a cuprizone-induced MS mouse model. Forty adult male mice were randomly assigned to four groups (n = 6 per group) of the control group; saff group with an intraperitoneal injection of 50 mg/kg saff for 35 days; Cpz + saff group with intraperitoneally injected with 50 mg/kg saff and feeding with 0.2% of Cpz daily, 35 days;and Cpz group feeding with 0.2% of Cpz daily for 35 days. Testicular tissue was collected for histological evaluation by stereological methods as well as analysis of the gene expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), Bcl-2, and Bax using real-time PCR. Enzymatic activity of SOD, GPx, and CAT was also assessed. Histopathological analysis revealed significant testicular atrophy and degenerative changes in the MS group, accompanied by reduced seminiferous tubule diameter and epithelial thickness. Saffron administration improved these parameters, preserved testicular architecture, and increased the number of spermatogenic cells. Moreover, saffron treatment significantly upregulated the mRNA expression and activity of antioxidant enzymes (SOD, GPx, and CAT), increased Bcl-2 expression, and downregulated Bax expression. Saffron exhibits protective effects against MS-induced testicular damage by enhancing antioxidant defenses and modulating apoptosis-related gene expression. These findings suggest the potential therapeutic role of saffron in preserving male reproductive function in the context of MS.
Indexed as
Identifiers
40455336What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.