Evidence map›Paper›PMID 40455356›Full record

ArticleMagma (New York, N.Y.)2025

A dedicated phantom for exploring the interplay of fat and paramagnetic substances in quantitative susceptibility mapping.

Simon Graf, Josefine Trapp, Maik Rothe, Alexander Gussew, Walter A Wohlgemuth, Andreas Deistung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simon GrafUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany. simon.graf@uk-halle.de.ORCID http://orcid.org/0009-0006-7684-966X
Josefine TrappUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.
Maik RotheUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.
Alexander GussewUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.
Walter A WohlgemuthUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.
Andreas DeistungUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.

Funding

Deutsche Forschungsgemeinschaft INST 271/ 406-1 FUGGEuropean Regional Development Fund ERDF - IP* 1bEuropean Regional Development Fund ZS/2021/06/158189
6 · The paper itself

Abstract

objectiveAccurate quantitative tissue characterization in organs with considerable fat content, like the liver, requires thorough understanding of fat's influence on the MR signal. To continue the investigations into the use of quantitative susceptibility mapping (QSM) in abdominal regions, we present a dedicated phantom that replicates liver-like conditions in terms of effective transverse relaxation rates (R MATERIALS AND

methodsThe spherical agar phantom consists of nine smaller spheres (diameter: 3 cm) doped with a paramagnetic substance (iron nanoparticles or manganese chloride) and fat (peanut oil), embedded in a large agar sphere (diameter: 14 cm), ensuring no barriers exist between the enclosed spheres and their surrounding medium. Concentrations were selected to represent both healthy and pathologic conditions. 3T MRI measurements for relaxometry, fat-water imaging, and QSM were conducted with the head coil and for

resultsThe phantoms' relaxation and magnetic properties are in similar range as reported for liver tissue. Substantial alterations in local field and susceptilibty maps were observed in regions with elevated fat and iron content, where fat correction of the local field via chemical shift-encoded reconstruction effectively reduced streaking artifacts in susceptibility maps and substantially increased susceptibility values. Linear regression analysis revealed a consistent linear relationship between R DISCUSSION: We developed a versatile phantom to study fat-iron interactions in abdominal imaging, facilitating the optimization and comparison of susceptibility processing methods in future research.

Indexed as

Adipose TissueMagnetic Resonance ImagingPhantoms, ImagingAbdomenAlgorithmsHumansImage Processing, Computer-AssistedIronLiverProtonsIronProtonsIronPhantomQuantitative susceptibility mappingRelaxometryWater–fat separation

Identifiers

PMID40455356
PMCPMC12638357

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.