Evidence map›Paper›PMID 40455381›Full record

ArticleAnnals of nuclear medicine2025

Establishment of a

Xue Zhang, Kenichi Nakajima, Wanda Acampa, Roberta Assante, Adriana D'Antonio, Koichi Okuda, Kunihiko Yokoyama, Seigo Kinuya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xue ZhangDepartment of Nuclear Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8640, Japan.
Kenichi NakajimaDepartment of Nuclear Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8640, Japan. nakajima@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-7188-8746
Wanda AcampaDepartment of Advanced Biomedical Science, University Federico II of Naples, Naples, Italy.
Roberta AssanteDepartment of Advanced Biomedical Science, University Federico II of Naples, Naples, Italy.
Adriana D'AntonioDepartment of Advanced Biomedical Science, University Federico II of Naples, Naples, Italy.
Koichi OkudaDepartment of Radiological Technology, Hirosaki University School of Health Sciences, Hirosaki, Japan.
Kunihiko YokoyamaPublic Central Hospital of Matto Ishikawa, Hakusan, Japan.
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8640, Japan.

Funding

JSPS Grants-in-Aid for Scientific Research 23K07203
6 · The paper itself

Abstract

purposeWe aimed to develop

methodsThis study included 55 Japanese and 33 Italian patients without cardiac or neurological diseases associated with Lewy bodies. Single-photon emission computed tomography (SPECT) images were acquired 20 min and 3-4 h after

resultsThe average uptake in the anterior segments was lower in the It-NDB and differences were more pronounced in males. The JpIt-NDB closely aligned with both the Jp-NDB and It-NDB. Clinical validation indicated that HF was identified more accurately by automated defect scores derived from the JpIt-NDB than visual scores (area under the receiver operating characteristic (ROC) curve (AUC): 0.827 vs. 0.683; P = 0.032). Combining JpIt-NDB-derived scores based on the heart-to-mediastinum ratio (HMR) significantly enhanced diagnostic accuracy (early and late AUCs: 0.960 and 0.952, respectively).

conclusionsThe combined JpIt-NDB accurately diagnosed HF in Japanese and European patients, while the defect scores correlated closely to Jp- and It-NDBs. Integrated HMR and NDB defect scores significantly enhanced cardiac assessment precision, which offers promise for future investigations into cardiac innervation imaging.

Indexed as

3-IodobenzylguanidineDatabases, FactualTomography, Emission-Computed, Single-PhotonAgedAged, 80 and overAsian PeopleFemaleHeart FailureHumansItalyJapanMaleMiddle Aged3-IodobenzylguanidineCardiomyopathyCoronary artery diseaseDefect scoreSympathetic imaging

Identifiers

PMID40455381
PMCPMC12378134

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.