Evidence map›Paper›PMID 40455956›Full record

ArticleThe Journal of physiology2025

Seizure-related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome.

Benjamin L Kreitlow, Ana T Novella-Maciel, Ariana M Hernández Vázquez, Gordon F Buchanan

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin L KreitlowDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0001-9747-7531
Ana T Novella-MacielDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Ariana M Hernández VázquezDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0009-0002-2134-9343
Gordon F BuchananDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0003-2371-4455

Funding

Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
Serotonergic circuit mechanisms in postictal recovery and arousalR01NS129722 · NINDS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2023 to 2026
$2.4M
NIGMS NIH HHS T32 GM139776NINDS NIH HHS R01 NS129722
6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the most extreme consequence of epilepsy. SUDEP typically occurs at night. Because humans sleep at night, these nighttime deaths are often attributed to seizures arising from sleep. Nocturnal mice also experience more seizure-associated deaths during the nighttime. This could represent timing that is under circadian control. To examine this, male and female Scn1a

Indexed as

Circadian RhythmEpilepsies, MyoclonicSeizuresSleepSudden Unexpected Death in EpilepsyAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLNAV1.1 Voltage-Gated Sodium ChannelNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mousecircadian rhythmepilepsyseizuresleepSUDEP

Identifiers

PMID40455956
PMCPMC12206440

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.