Evidence map›Paper›PMID 40456602›Full record

ArticleGenome research2025

Regeneration alters open chromatin and

Yichao Zhou, Venkatasai Rahul Dogiparthi, Hannah L Harris, Suhita Ray, Avik Choudhuri, Song Yang, Yi Zhou, Leonard I Zon, M Jordan Rowley, Kyle J Hewitt

Abstract read
In one paragraph

Article in Genome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yichao ZhouDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.ORCID 0000-0003-2381-3365
Venkatasai Rahul DogiparthiDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Hannah L HarrisDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Suhita RayDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Avik ChoudhuriHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Song YangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Yi ZhouHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Leonard I ZonHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
M Jordan RowleyDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.ORCID 0000-0002-5135-9596
Kyle J HewittDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA; kyle.hewitt@unmc.edu.ORCID 0000-0003-1946-625X

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
Target Validation CoreP20GM121316 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ADRIAN R BLACK · 2018 to 2026
$23.5M
Hematology Central Coordinating Center (HCCC) for the NIDDK Hematology Centers ProgramU24DK126127 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, DEREK L STIREWALT · 2020 to 2026
$7.5M
Transcriptional response to signaling during hematopoiesisR01HL144780 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZON, LEONARD IRA · 2019 to 2022
$2.1M
Functional characterization of the endothelial cell niche for hematopoietic stem cellsR01DK140372 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEONARD Ira ZON · 2024 to 2026
$2.1M
Fine-Scale Genome Folding Relative to Transcription and LocationR35GM147467 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael Jordan Rowley · 2022 to 2026
$2.0M
GATA Factor Mechanisms in Erythroid RegenerationR01HL155439 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HEWITT, KYLE J · 2021 to 2025
$1.9M
Stress Granules in Red Blood Cell DevelopmentR01DK143991 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEONARD Ira ZON · 2025 to 2026
$1.6M
NCI NIH HHS P30 CA036727NHLBI NIH HHS R01 HL144780NHLBI NIH HHS R01 HL155439NIDDK NIH HHS R01 DK140372NIDDK NIH HHS R01 DK143991NIDDK NIH HHS U24 DK126127NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM121316NIGMS NIH HHS R35 GM147467
6 · The paper itself

Abstract

Stress erythropoiesis elevates the rate of red blood cell (RBC) production as a physiological response to stressors such as anemia or hypoxia. In acute anemia, RBC progenitors and precursors temporarily rewire their transcriptome, up- and downregulating hundreds of genes to accelerate the production of mature RBCs. Effective regeneration requires communication between critical cytokine signals (e.g., BMP4) and

Indexed as

AnemiaChromatinErythroid Precursor CellsRegenerationRegulatory Sequences, Nucleic AcidAnimalsBone Morphogenetic Protein 4ErythropoiesisGene Expression RegulationHumansMiceBone Morphogenetic Protein 4Chromatin

Identifiers

PMID40456602
PMCPMC12212076

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.