Evidence map›Paper›PMID 40456733›Full record

ArticleNature communications2025

Inflammatory diseases and risk of lung cancer among individuals who have never smoked.

Monica E D'Arcy, Ruth M Pfeiffer, Marie C Bradley, Phuc H Hoang, Thi-Van-Trinh Tran, John P McElderry, Mengying Li, Michael Kebede, Curt T DellaValle, Sara Rivas and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Monica E D'ArcyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. monica.darcy@rutgers.edu.ORCID http://orcid.org/0000-0002-1586-9089
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. pfeiffer@mail.nih.gov.
Marie C BradleyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-9265-8525
Thi-Van-Trinh TranDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Mengying LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Michael KebedeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Curt T DellaValleDivision of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0001-6616-8904
Sara RivasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Youjin WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Shahinaz M GadallaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-3255-8143
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. landim@nih.gov.ORCID http://orcid.org/0000-0003-4507-329X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer in never-smokers (LCINS) is a leading cause of cancer death globally, but no screening programs for LCINS exist. To identify medical conditions that could serve as markers of LCINS risk, we conducted a nested case-control study within the United Kingdom's Clinical Practice Research Datalink (CPRD-GOLD), consisting of 1581 LCINS cases and 14,318 never-smoking controls. Conditions significantly associated with LCINS 1-10 years before the index date were validated in an independent dataset, CPRD-Aurum (2188 LCINS cases, 19,597 never-smoking controls). These conditions include Chronic Obstructive Pulmonary Disease/Emphysema (COPD); gastroesophageal reflux disease (GERD); bronchitis and tracheitis; diabetes mellitus type 1; and gastritis and non-infective gastroenteritis and colitis. Adjusting for medication use only slightly attenuated these associations. Overall, inflammatory diseases appear to be important in LCINS pathogenesis although further studies need to confirm these associations. Conditions such as GERD or COPD could be considered as part of eligibility criteria for future LCINS screening programs.

Indexed as

InflammationLung NeoplasmsNon-SmokersAdultAgedBronchitisCase-Control StudiesFemaleGastritisGastroesophageal RefluxHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRisk FactorsSmoking

Identifiers

PMID40456733
PMCPMC12130270

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.