Evidence map›Paper›PMID 40456782›Full record

ArticleScientific reports2025

Exploring the binding interaction of 1,4-naphthoquinone derivative-human serum albumin complex by biophysics and molecular simulation.

Francis Ayimbila, Tanawut Tantimongcolwat, Waralee Ruankham, Ratchanok Pingaew, Veda Prachayasittikul, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francis AyimbilaCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Tanawut TantimongcolwatCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Waralee RuankhamDepartment of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Ratchanok PingaewDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand.
Veda PrachayasittikulCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Virapong PrachayasittikulDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Supaluk PrachayasittikulCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Kamonrat PhopinCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand. kamonrat.php@mahidol.ac.th.

Funding

Srinakharinwirot University and National Science, Research and Innovation Fund (NSRF) grant no. 029/2566
6 · The paper itself

Abstract

A set of 1,4-naphthoquinone (1,4-NQ) derivatives possesses various pharmaceutical activities. Among them, a synthetic 2-(4-methoxyanilino)naphthalene-1,4-dione (MN) is found to be non-cytotoxic to the normal MRC-5 cells and prevent neuronal SH-SY5Y cell damage. To explore the underlying interaction mechanism of MN in the circulatory system, in silico and multi-spectroscopic techniques were employed to investigate the complex of human serum albumin (HSA) and MN. The interaction between HSA and MN exhibited static fluorescence with a potential dynamic mechanism, as K

Indexed as

NaphthoquinonesSerum Albumin, HumanBinding SitesCircular DichroismHumansHydrophobic and Hydrophilic InteractionsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingSpectroscopy, Fourier Transform InfraredThermodynamics1,4-naphthoquinoneNaphthoquinonesSerum Albumin, Human1,4-NaphthoquinoneBiophysicsHuman serum albuminMolecular simulationPharmacokinetics

Identifiers

PMID40456782
PMCPMC12130506

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.