Observational studyThe international journal of cardiovascular imaging2025
Thoracic aortic calcifications on chest radiographs and incident major adverse limb events in cardiovascular disease patients.
Observational study in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thoracic aortic calcifications (TAC) are a common finding in medical imaging. We assessed the association between TAC on chest radiographs and major adverse limb events (MALE), other cardiovascular outcomes, and mortality in cardiovascular disease patients. A total of 4680 patients were included from the prospective Utrecht Cardiovascular Cohort-Second Manifestation of ARTerial disease cohort. TAC severity was classified based on chest radiographs by certified readers as mild, moderate, and severe. Multivariate cox proportional hazard models were utilized to assess associations between TAC and incident MALE defined as major amputation, peripheral revascularization or thrombolysis in the lower limb. Secondary endpoints included major adverse cardiovascular events (MACE: stroke, myocardial infarction, and vascular death), and all-cause mortality. A total of 4680 patients were included. TAC was present in 1789 (38%) patients. After a median follow-up of 11.8 years (interquartile range: 7.6-15.7 years), 426 MALE, 992 MACE, and 1387 deaths occurred. TAC presence was associated with incident MALE after adjustments, (hazard ratio (HR):2.14;95%CI:1.73-2.65) and this risk increased with TAC severity (HR
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