ArticleAesthetic plastic surgery2025
Effect of Fixed-Angle and Horizontal Rotor Centrifugation on Optimized Platelet-Rich Plasma Preparation.
Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Progress in research on the effects of Platelet-Rich Plasma (PRP) ovarian injection on early ovarian reserve dysfunction and premature ovarian insufficiency.Journal of ovarian research · 2026Review
- Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain: From Standardized Preparation to Multi-Omics-Guided Precision Therapy.Journal of pain research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPlatelet-rich plasma (PRP) is extensively used in regenerative medicine; however, its preparation lacks standardization. The difference in rotor angle between fixed-angle and horizontal rotors influences PRP quality. This study aims to compare the effects of these two rotor types on PRP preparation.
methodsA total of 15 subjects were enrolled in the study, with each subject donating 80 ml of whole blood, which was then divided into two separate tubes, each containing 40 ml. PRP was prepared using two rounds of centrifugation with both fixed-angle and horizontal rotors under optimal parameters. Platelet recovery, concentration, growth factor content, and effects on cell co-culture were assessed.
resultsThe fixed-angle centrifuge demonstrated higher platelet recovery efficiency, increased platelet content, and greater PDGF-BB levels in the PRP, with no significant change in CD62P expression. Co-culture assays showed enhanced cell proliferation and migration with PRP prepared using the fixed-angle rotor compared to the horizontal rotor.
conclusionsUnder appropriate centrifugation parameters, the fixed-angle centrifuge can extract higher quality PRP in a shorter time. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
40456994What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.