ArticleNature immunology2025
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- The plasma metabolome and clinical features of patients with coeliac disease in Northwest China.Annals of medicine · 2026Article
- CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Palmitic acid coordinates impaired visceral adipose ICOShi Treg-mediated immunosuppression and systemic metabolic disturbance during obesity.The Journal of clinical investigation · 2026Article
- The FAM234A-USP4 axis governs T-cell fate through the dual regulation of mTOR and RORγt.Cellular & molecular immunology · 2026Article
- Tuft cells protect against intestinal inflammation through histone deacetylase 3.Mucosal immunology · 2026Article
- Gut microbiota-derived succinate links proteostasis collapse to α-synuclein pathology and aging.iScience · 2026Article
- Hyperglycemia aggravates vitiligo through succinate/SUCNR1-mediated T cell activation.The Journal of clinical investigation · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Metabolic reprogramming of Th17/Treg imbalance in autoimmune thyroid diseases.Cell communication and signaling : CCS · 2026Review
- Microbiome-Based Therapies in Ulcerative Colitis: Mechanisms, Clinical Evidence, and a Precision-Medicine Framework.Biomedicines · 2026Article
- Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation.Aging cell · 2026Article
- Fecal Microbiota Transplantation from APP/PS1 Mice Induces Th17-Related Inflammatory Parameters and Pathological Changes in the Gut-Brain Axis of Healthy C57BL/6J Mice.International journal of molecular sciences · 2026Article
- Dynamic regulation of TBK1 lactylation shapes antiviral immune responses.Cellular & molecular immunology · 2026Article
- Dysfunction of mitochondria in intestinal epithelial cells: a key player in the pathogenesis of inflammatory bowel diseases.Gastroenterology report · 2026Review
- Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026Review
- Lacticaseibacillus rhamnosus LRa05 mitigates DSS-Induced colitis via boosting beneficial gut microbiota and facilitating CD4⁺Foxp3⁺ Treg differentiation.BMC microbiology · 2026Article
- Widely targeted metabolomics and machine learning identify succinate as a key metabolite in sepsis-associated encephalopathy.iScience · 2026Article
- Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Pulmonary injury in inflammatory bowel disease: intestinal barrier disruption, gut-lung axis remodeling, and treatment-related lung toxicity.Frontiers in immunology · 2026Review
- PCK2-Mediated PQBP1 Lactylation Promotes Asthmatic Inflammation through PRMT5 Inhibition.Research (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Hai Wang *Department of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Danqing Hu *Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, University of Science and Technology, Wuhan, PR China.
Yang ChengDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Qiong GaoDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kun LiuDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Nikita L ManiDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Amy Y TangDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Radhika IyerDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Beixue GaoDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leyu SunDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Qi ZhouDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Qin YuDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Samuel E WeinbergDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Xiaoyu ZhangDepartment of Chemistry, Northwestern University, Evanston, IL, USA.
Yingzi CongDivision of Gastroenterology and Hepatology, Department of Medicine, Gastroenterology and Hepatology, Northwestern Memorial Hospital, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4167-7395
Parambir S DulaiDivision of Gastroenterology and Hepatology, Department of Medicine, Gastroenterology and Hepatology, Northwestern Memorial Hospital, Chicago, IL, USA.
Yana ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. zhangyn95@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-0405-2943
Zheng LiuDepartment of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, University of Science and Technology, Wuhan, PR China. zhengliuent@hotmail.com.ORCID http://orcid.org/0000-0002-4168-6702
Deyu FangDepartment of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. fangd@northwestern.edu.ORCID http://orcid.org/0000-0002-4211-2751
Funding
Novel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MClinical analysis and therapeutic development of exosomal ACE2R01AI167272 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Deyu Fang, Huiping Liu · 2022 to 2026
$3.6MA deubiquitination module controls Treg adaptation to tumor microenvironmentR01CA257520 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU, ZHANG, BIN · 2021 to 2025
$2.8MChemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7MIdentifying Neutrophil Specific Mechanisms for Resistance to Biologics in Ulcerative ColitisR01DK135620 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Parambir Singh Dulai, Ronen Sumagin · 2023 to 2026
$2.7MSTING signaling in T cells regulation of intestinal homeostasis and inflammatorybowel diseasesR01DK124132 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2024
$2.5MRegulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2MGut microbiota metabolite sensing licenses IEC to cross talk with T cells to inhibit intestinal inflammationR01DK135193 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Yingzi Cong · 2023 to 2026
$2.2MMolecular mechanisms underlying circulating tumor cell aggregationR01CA245699 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, HUIPING · 2020 to 2024
$2.0MTargeting a Treg deubiquitinase in antitumor immune therapyR01CA232347 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2018 to 2022
$1.7MChemistry of Life Processes Predoctoral Training ProgramT32GM149439 · NIGMS · NORTHWESTERN UNIVERSITY · PI NEIL L KELLEHER · 2023 to 2026
$1.6MDevelop a novel therapy with immuno- and onco-targeting dual efficacies to treat the triple negative breast cancerR01CA288387 · NCI · NORTHWESTERN UNIVERSITY · PI Deyu Fang, Huiping Liu · 2025 to 2026
$1.3MFoundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) CA232347Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01CA257520Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01DK120330Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01DK126908Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) RO1DK124132Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) RO1DK135193Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) RO1DK135620Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) T32GM105538Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) T32GM149439NCI NIH HHS F31 CA287701NCI NIH HHS R01 CA232347NCI NIH HHS R01 CA245699NCI NIH HHS R01 CA257520NCI NIH HHS R01 CA288387NCI NIH HHS R01 CA298232NCI NIH HHS UG3 CA256967NCI NIH HHS UH3 CA256967NIAID NIH HHS R01 AI167272NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK124132NIDDK NIH HHS R01 DK126908NIDDK NIH HHS R01 DK135193NIDDK NIH HHS R01 DK135620NIGMS NIH HHS T32 GM105538NIGMS NIH HHS T32 GM149439
Abstract
Succinate levels are increased in inflammatory bowel disease (IBD), but its role in disease pathogenicity remains unknown. Here we showed that succinate promoted colitis in mice by reducing the expression of FOXP3 and increasing the expression of interleukin-17 in regulatory T (T
Indexed as
ColitisForkhead Transcription FactorsInflammatory Bowel DiseasesSuccinic AcidT-Lymphocytes, RegulatoryAnimalsFemaleHumansInflammationInterleukin-17Ketoglutarate Dehydrogenase ComplexMaleMiceMice, Inbred C57BLMice, KnockoutProteolysisForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseInterleukin-17Ketoglutarate Dehydrogenase ComplexSuccinic Acid
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.