Evidence mapPaperPMID 40457345Full record

ReviewVirology journal2025

Herpesvirus-associated diseases: biomarkers and advancements in clinical research.

Lu Lu, Miao Fan, Xu Li, Wen Su, Xinyu Wang, Yuhua Xue, Lin Ma, KaiHu Yao, Ying Liu, Lei Jia and 1 more

Abstract readReview
In one paragraph

Review in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Current Status ofPathogens (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lu Lu *Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China.
Miao Fan *Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China.
Xu Li *Department of Dermatology, The First Hospital of Hohhot, Hohhot, 010030, China.
Wen SuLaboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China.
Xinyu WangLaboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China.
Yuhua XueFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Affiliated Xiamen Eye Center, Xiamen University, Xiamen, 361005, China.
Lin MaLaboratory of Dermatology, Beijing Children's Hospital, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
KaiHu YaoLaboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China.
Ying LiuLaboratory of Dermatology, Beijing Children's Hospital, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. ying_lemon@aliyun.com.
Lei JiaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China. 15001193408@163.com.
Dan YuLaboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing, 100045, China. danyu@ccmu.edu.cn.

Funding

Chinese Institutes for Medical Research and Capital Medical University Grant number: KCB2301Chinese Institutes for Medical Research, Beijing Grant number: CX23YQ04
6 · The paper itself

Abstract

Herpesviruses are responsible for a broad spectrum of diseases that impact various tissues and organs, which could lead to complex pathological manifestations and severe complications. These infections represent a significant burden on global public health. Increasing researches have focused on identifying biomarkers associated with herpesvirus-related diseases and the underlying mechanisms. Studies using clinical samples may better reflect the molecular basis of disease progression, offering new insights into the illustration of disease development. This review provides a comprehensive summary of recent progress in biomarker discovery across a range of disease conditions caused by herpesviruses, highlighting the latest experimental findings and clinical observations, with a particular focus on the potential applications of these biomarkers in clinical settings. Additionally, we discuss the major challenges in the current research of herpesvirus-associated diseases, intending to foster the discovery of novel diagnostic and therapeutic strategies and deepen our understanding of herpesvirus pathogenesis.

Indexed as

BiomarkersHerpesviridaeHerpesviridae InfectionsAnimalsHumansBiomarkersBiomarkerClinical researchHerpesvirus-associated diseasesHerpesviruses

Identifiers

PMID40457345
PMCPMC12128367

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.