ArticleBMC pulmonary medicine2025
(Pre-) atherosclerotic vessel changes in patients with chronic obstructive pulmonary disease and eosinophilia.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is accompanied by systemic inflammation and an increased risk of cardiovascular diseases, including atherosclerosis and abdominal aortic aneurysms. Eosinophilic inflammation is common in COPD, but little is known about the role of eosinophilia in atherogenesis.
objectiveThe study aims to investigate a possible link between the blood eosinophil count (BEC) in stable COPD patients and arterial vessel changes of the infrarenal abdominal aorta (AA) and common carotid arteries (CCAs).
methodsOne hundred seven patients were acquired. Ultrasonography imaging was employed to assess atherosclerotic plaques and AA diameter, vascular speckle tracking was used to evaluate vessel movement by vascular strains of the AA and CCAs. Patients were divided into two groups, comparing a low (< 300/µl) and high (≥ 300/µl) BEC. The circumferential (rad.) strains and aortic diameter were defined as primary outcome measures.
resultsThe strains values of the left and right CCA did not differ between the groups (left CCA: 3.0 ± 1.6% vs. 3.6 ± 1.5%, p = .053, right CCA: 3.5 ± 1.8% vs. 4.1 ± 1.8%, p = .127), neither did the aortic diameter (1.88 ± 0.8 vs. 1.79 ± 0.8 cm, p = .674) or atherosclerotic plaque burden. There were lower strain values of the abdominal aorta (3.6 ± 1.5 vs. 2.8 ± 1.4, p = .014), reduced radial displacement (0.16 ± 0.1 vs. 0.11 ± 0.1 mm, p = .011) and an association of BEC and strain values in linear regression analysis (b = -0.001 [95% CI: -0.003-0.001], p = .044), indicating an impaired vascular movement. However, it could not detect an association between BEC and strains of the CCAs (p = .664 resp. .576) or the aortic diameter (p = .672).
conclusionThe study shows no persuasive association between BEC in COPD and vascular strain values or aortic diameter. However, BEC was associated with reduced movement of the AA.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.