Evidence map›Paper›PMID 40457620›Full record

ArticleMagnetic resonance in medicine2025

Establishing standardized healthy reference distributions and values for multisite

Suphachart Leewiwatwong, Aryil Bechtel, David Mummy, Shuo Zhang, Junlan Lu, Anna Costelle, Zackary I Cleveland, Matthew Willmering, Juan Parra-Robles, Sean Fain and 3 more

Abstract readMulticenter Study
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Correlating Pulmonary Hemodynamics With HPMagnetic resonance in medicine · 2026
    Article
  2. Article
  3. Article
  4. Dynamic RBC-To-Membrane Ratio inMagnetic resonance in medicine · 2026
    Article
  5. Article
  6. Combining hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suphachart LeewiwatwongBiomedical Engineering, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0009-0000-6198-3301
Aryil BechtelRadiology, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-2928-3898
David MummyRadiology, Duke University, Durham, North Carolina, USA.
Shuo ZhangRadiology, Duke University, Durham, North Carolina, USA.
Junlan LuMedical Physics Graduate Program, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-5023-7901
Anna CostelleMedical Physics Graduate Program, Duke University, Durham, North Carolina, USA.
Zackary I ClevelandDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0001-6195-9061
Matthew WillmeringDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-4356-9622
Juan Parra-RoblesDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Sean FainDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.
Andrew D HahnDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-0246-2108
Robert M TigheSchool of Medicine, Duke University, Durham, North Carolina, USA.
Bastiaan DriehuysBiomedical Engineering, Duke University, Durham, North Carolina, USA.

Funding

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Xenon MRI in Pulmonary HypertensionR01HL153872 · NHLBI · DUKE UNIVERSITY · PI DRIEHUYS, BASTIAAN, RAJAGOPAL, SUDARSHAN K · 2021 to 2024
$2.9M
Hyperpolarized Xe-129 MRI for Functional Lung PhenotypingS10OD026960 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2019 to 2019
$600k
NHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771NIH HHS S10 OD026960NIH/NHLBI R01HL105643NIH/NHLBI R01HL12677NIH/NHLBI R01HL153872
6 · The paper itself

Abstract

purposeTo establish standardized reference distributions and values for 1-point Dixon

methodsHealthy participants from three centers-Duke University (Siemens), Cincinnati Children's Hospital (Philips), and the University of Iowa (General Electric)-underwent pulmonary function testing and a standardized

resultsThe reference distributions were consistent across sites and platforms for both imaging and spectroscopy. Combined imaging reference means were ventilation = 0.71 ± 0.14, membrane (M)/gas = 0.97 ± 0.27 × 10

conclusionsThese reference distributions provide a robust benchmark for 3T

Indexed as

Magnetic Resonance ImagingXenon IsotopesAdolescentAdultFemaleHealthy VolunteersHumansImage Processing, Computer-AssistedMagnetic Resonance SpectroscopyMaleReference ValuesRespiratory Function TestsYoung AdultXenon-129Xenon Isotopes129Xe gas exchange MRI/MRS3 Tcross‐platformmulticenterpulmonaryreference values

Identifiers

PMID40457620
PMCPMC12310359

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.