Observational studyThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2026
Associations of Sleep Disordered Breathing and Neurodevelopment with Pre-Speech Function in 2-Month-Old Infants with Oral Cleft: A Feasibility Study.
Observational study in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
ObjectiveEvaluate feasibility of a study to measure emergent language and pre-speech skills in infants with and without oral cleft. Functioning was assessed in relation to nighttime oxygenation and neural structure.DesignObservational, case/control study.SettingData was obtained at two clinical settings (University of Iowa and University of Pittsburgh Children's Hospital).ParticipantsTwenty infants with and without oral cleft were enrolled and evaluated at 2 months of age. Seven additional infants the same age with a subset of measures from an earlier study were also included. The combined sample included 27 participants: 5 with cleft lip only (iCL), 8 with cleft lip and palate (iCLP), and 14 unaffected (UA).Main Outcome MeasuresParent ratings of general functioning and emergent language (Bayley-4 SEABQ), acoustic measures of vocalizations, overnight pulse oximetry, and structural Magnetic resonance imaging (MRI) scans.ResultsSuccess rates for measures were high for emergent language and vocal acoustics (100% and 89%, respectively) and moderate for oximetry and MRI scans (63% and 70%, respectively). Participants with iCLP had the lowest outcomes for emergent language and vocal acoustics, as well as the highest number of desaturations and lowest myelin intensity.ConclusionsThe results of this study
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