ArticleFrontiers in aging neuroscience2025
Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A study on risk prediction of decline in self-care ability one month after discharge in postoperative colorectal cancer patients based on routine clinical indicators.Frontiers in surgery · 2026Article
- Development and validation of the C-reactive protein-triglyceride-glucose index for predicting short- and long-term mortality in critically ill patients with coronary artery disease: a multicenter cohort study.Frontiers in cardiovascular medicine · 2026Article
- Association of the triglyceride-glucose series indices with hypertension and pre-hypertension in Anhui China.Scientific reports · 2025Article
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Authors and funding
6 authors.
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Abstract
Background: The triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability. Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings. Results: The diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR = 1.23, 95%CI: 1.16-1.30, Conclusion: Our findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations.
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