ArticleFrontiers in medicine2025
Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto's thyroiditis: insights from efferocytosis regulation.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Efferocytosis: unifying pathogenic hub in metabolic disorders-mechanistic landscapes, targeted therapies and translational bottlenecks.Frontiers in immunology · 2026Review
- Enhancing Chemosensitivity With Quercetin: Mechanistic Insights Into MerTK and Associated Signaling Pathways.Cancer reports (Hoboken, N.J.) · 2025Review
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2 authors.
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Abstract
Background: Patients with obesity-associated Hashimoto's thyroiditis (HT) have been prevalent in clinical practice. Obesity is a risk factor for HT as it promotes pro-inflammatory processes and influences the balance of immune cell subsets. Traditional Chinese medicine (TCM) is characterized by its multi-component and multi-target approach and shows potential in treating HT. Specifically, TCM can reduce thyroid antibody levels and alleviate clinical symptoms without impairing thyroid function. Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation. Methods: Targets of five high-frequency herbs ( Results: Efferocytosis emerged as the key mechanism in the context of five herbs and obesity-associated HT. Quercetin was identified as the primary active ingredient responsible for efferocytosis, and it bound well with efferocytosis-related targets. Conclusion: This study's key finding is that five high-frequency prescribed herbs may treat obesity-associated HT through efferocytosis. This provides new evidence to support the use of TCM in treating obesity-associated HT.
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