Evidence map›Paper›PMID 40458801›Full record

ArticleFrontiers in pharmacology2025

Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells.

Yuanyuan Wang, Siqi Liu, Keyi Lu, Erping Xu, Zhibin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Extracellular Vesicles Derived fromNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Frontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanyuan WangCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Siqi LiuCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Keyi LuCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Erping XuCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Zhibin WangDepartment of Critical Care Medicine, School of Anesthesiology, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal elevations in the mortality of intestinal epithelial cells (IECs) are indicative of intestinal inflammation. Necroptosis of IECs represents a pro-inflammatory form of cell death, and modulation of IECs necroptosis may mitigate subsequent intestinal inflammation and preserve the integrity of the intestinal barrier. Currently, safe and effective preventive measures are lacking. In the Traditional Chinese Medicine theory, necroptosis of IECs leads to the destruction of the intestinal barrier in a manner associated with "heat and toxicity", exacerbating intestinal inflammation. Heat shock protein 90 (HSP90) has been identified as a regulator of key proteins involved in necroptosis signal pathway including RIPK1/3 and MLKL. Gambogic acid (GA), the primary active compound found in

Indexed as

Gambogic acidHsp90IECsnecroptosisulcerative colitis

Identifiers

PMID40458801
PMCPMC12127353

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.