Evidence map›Paper›PMID 40458912›Full record

ArticleChemMedChem2025

Novel 4,5-Dihydrothiazole-Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents.

Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła-Tarłowska, Jolanta H Kotlińska, Kinga Gawel and 9 more

Abstract read
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giorgia AndreozziDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.
Natalia KarkoszkaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a Str, 20-093, Lublin, Poland.
Rosa SparacoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.
Angela CorvinoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.
Beatrice SeverinoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.
Vincenzo SantagadaDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.ORCID https://orcid.org/0000-0001-8377-8990
Elisa MagliDipartimento di Sanità Pubblica, Università di Napoli Federico II, Via Pansini, 5, 80131, Naples, Italy.
Ewa Gibuła-TarłowskaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a Str, 20-093, Lublin, Poland.
Jolanta H KotlińskaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a Str, 20-093, Lublin, Poland.
Kinga GawelDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego Str. 8b, 20-090, Lublin, Poland.
Raffaele CapassoDipartimento di Agraria, Università degli Studi di Napoli "Federico II", Via Università 100, Portici, 80055, Naples, Italy.
Anna LesniakDepartment of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland.
Nataliia SemenkoDepartment of the Surgery, Anesthesiology and Intensive care, Bogomolets National Medical University, Kyiv, Ukraine.ORCID https://orcid.org/0000-0001-8235-386X
Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., 20-093, Lublin, Poland.
Anna BielenicaChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str, 02-097, Warsaw, Poland.
Grażyna BiałaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a Str, 20-093, Lublin, Poland.
Giuseppe CaliendoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.ORCID https://orcid.org/0000-0002-5098-6045
Ewa KędzierskaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a Str, 20-093, Lublin, Poland.
Ferdinando FiorinoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 80131, Napoli, Italy.ORCID https://orcid.org/0000-0001-7357-5751

Funding

Medical University of Lublin DS 19 for EKMedical University of Lublin DS448,prof.WaldemarA.TurskiMedical University of Lublin DS 449 for KG
6 · The paper itself

Abstract

The synthesis of a new series of long-chain arylpiperazine as serotoninergic ligands (FG 1-18) is described. The combination of structural elements including heterocyclic nucleus, propyl chain, and 4,5-dihydrothiazol-2-ylphenylpiperazines leads to the preparation of different derivatives tested for their affinity toward 5-HT

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsPiperazinesSerotonin AgentsThiazolesAnimalsDose-Response Relationship, DrugHumansMaleMiceMolecular Docking SimulationMolecular StructureRatsReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CAnti-Anxiety AgentsAntidepressive AgentsphenylpiperazinePiperazinesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin AgentsThiazoles(4,5‐Dihydrothiazol‐2‐yl) phenyl) piperazinesbinding assaysligand designserotoninstructure–activity relationships

Identifiers

PMID40458912
PMCPMC12321279

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.