Evidence map›Paper›PMID 40459639›Full record

ArticleLung2025

Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy.

Christopher Theroux, Christina Raker, Melissa Guillen, Annaly Aldana, Ashanti Avalos, F Dennis McCool, Ghada Bourjeily

Abstract read
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In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher TherouxDivision of Pulmonary Critical Care and Sleep Medicine, Warren Alpert Medical School of Brown University, 146 West River St, Suite 1K, Providence, RI, 02904, USA.
Christina RakerDepartment of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Melissa GuillenWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA.
Annaly AldanaWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA.
Ashanti AvalosWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA.
F Dennis McCoolDivision of Pulmonary Critical Care and Sleep Medicine, Warren Alpert Medical School of Brown University, 146 West River St, Suite 1K, Providence, RI, 02904, USA.
Ghada BourjeilyDivision of Pulmonary Critical Care and Sleep Medicine, Warren Alpert Medical School of Brown University, 146 West River St, Suite 1K, Providence, RI, 02904, USA. Ghada_Bourjeily@brown.edu.ORCID http://orcid.org/0000-0002-0543-4719

Funding

The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopmentU24GM150446 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2023 to 2026
$13.3M
Predictors of de novo development of obstructive sleep apnea in pregnancyR01HL130702 · NHLBI · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2016 to 2020
$2.6M
NHLBI NIH HHS R01 HL130702NIGMS NIH HHS U24GM150446
6 · The paper itself

Abstract

purposePregnancy is a risk factor for the development of obstructive sleep apnea (OSA) and for worsening of asthma; the interaction between the two disorders is not well described. We aimed to examine airway mechanics in pregnant patients with and without OSA and asthma.

methodsWe studied 217 women with BMI above 25 early in the second trimester of pregnancy. Airways resistance was measured using the forced oscillation technique at 5 Hz (R5), 20 Hz (R20), and 35 Hz (R35). All values were expressed as % predicted. level III sleep studies were scored according to the recommended AASM rules; OSA was diagnosed by AHI ≥ 5 events per hour. Asthma was defined by medical history and record review.

resultsOf the 217 women tested, 53 had OSA and 66 had asthma. R20 and R35 were increased in women with both OSA and asthma compared to those with neither asthma nor OSA (adjusted mean difference (aMD) for R20 was 19.7, CI 3.4-36.0, p value = 0.02; aMD for R35 was 36.9 CI 12.4-61.5, p value = 0.003). There was a significant increase in R35 for women with OSA as opposed to those without (aMD 17.6 (CI 1.4-33.8; p value = 0.03).

conclusionPregnant women with both OSA and asthma have higher central airways resistance and upper airway resistance as measured at R20 and R35, respectively, compared to those with neither OSA nor asthma. Further work is needed to understand mechanisms underlying the synergistic effects of OSA and asthma on airways mechanics.

Indexed as

Airway ResistanceAsthmaLungPregnancy ComplicationsSleep Apnea, ObstructiveAdultFemaleHumansPolysomnographyPregnancyRisk FactorsAirway resistanceAsthmaImpulse oscillometryObstructive sleep apneaPregnancy

Identifiers

PMID40459639

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.