ReviewBiochemical genetics2026
Oxidative Stress, Genetic Factors and Behavioral Responses to Chemical Exposure: Insights into Cancer Development in Zebrafish (Danio Rerio).
Review in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer research in animal models is critical for understanding disease mechanisms and testing potential therapies. Among the various models, zebrafish (Danio rerio) has gained prominence due to its genetic similarity to humans, rapid development, and transparency during early stages. The objective of this article is to explore the zebrafish as a powerful model for studying cancer, particularly focusing on the role of oxidative stress (OS) and genetic factors (oncogenes, tumor suppressor genes) in cancer progression. The interaction between oxidative stress, DNA damage, and genetic mutations is examined, highlighting how these processes contribute to tumor formation. Additionally, the study investigates the various behavioral tests used to assess the effects of carcinogenic and non-carcinogenic substances, such as sodium arsenate (As(V), N-ethyl-N-nitrosourea (ENU), dimethylbenzanthracene (DMBA), N-methyl-N1-nitro-N-nitrosoguanidine (MNNG), Atrazine and Methylmercury (MeHg) on zebrafish cognitive functions. The review included 170 papers published in English up to December 2024 and was conducted in accordance with PRISMA guidelines, using multiple electronic databases (Science Direct, PubMed and Google Scholar) to perform a comprehensive and systematic search using keywords. Through this approach, zebrafish emerge as a versatile model for cancer research, offering insights into both the physiological and behavioral impacts of chemical exposures.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.