Evidence map›Paper›PMID 40459689›Full record

ArticleBrain imaging and behavior2025

The hidden burden: cerebral small vessel disease and cognitive reappraisal failure in memory clinic older adults.

Renren Li, Weixin Xiao, Zengmai Xie, Jing Ma, Xiaoran Zheng, Jiaxin Yan, Xiaochen Zhang, Zhiyu Nie, Yunxia Li

Abstract read
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Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Renren Li *Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Weixin Xiao *Department of Neurology, Xiamen Haicang Hospital, Fujian, China.
Zengmai XieDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jing MaDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaoran ZhengDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiaxin YanDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaochen ZhangDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Zhiyu NieDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunxia LiDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. doctorliyunxia@163.com.

Funding

Project funding from Shanghai Municipal Health Commission No.2022JC018Shanghai Committee of Science and Technology 22Y11903500Shanghai Hospital Development Center Foundation SHDC12021110STI2030-Major Projects 2022ZD0211600the Key Discipline Project of Shanghai Pudong Hospital No.zdxk2020-09; No.Zdzk2024-05; No.YJYJRC202307the National Key R&D Program of China 2018YFC1314702the National Science Foundation of China No. 81671307
6 · The paper itself

Abstract

Emotion regulation is a vital life skill, and cognitive reappraisal (CR) is the most effective emotion regulation strategy, which plays a key role in healthy aging. In memory clinic patients, problems with emotion regulation difficulties and cognitive impairment are very common, often accompanied by signs of cerebral small vessel disease (CSVD) on their magnetic resonance imaging (MRI). Is there a correlation among cognitive reappraisal failure, cognitive impairment, and CSVD in these older adults? This study aims to investigate the question. A standardized emotion regulation task was used to measure CR ability. A total of 170 older adults were included in statistical analysis, of which 78 were considered as cognitive reappraisal failure (CR-Failure). All participants completed the emotion regulation task, neuropsychiatric assessments, and MRI scans, with traditional CSVD markers being evaluated. Our analysis indicated that CR ability is negatively correlated with scores on the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Additionally, logical memory and executive function are significant factors in CR utilization. A higher burden of CSVD or presence of cognitive impairment is an independent risk factor for cognitive reappraisal failure in memory clinic older adults. Furthermore, cognitive impairment significantly mediates the relationship between greater CSVD burden and CR failure.

Indexed as

Cerebral Small Vessel DiseasesCognitive DysfunctionEmotional RegulationAgedAged, 80 and overCognitionExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsCerebral small vessel diseaseCognitive impairmentCognitive reappraisalEmotional regulationExecutive function

Identifiers

PMID40459689

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.