Evidence mapPaperPMID 40459864Full record

ArticleJournal of integrative bioinformatics2025

Bioinformatic analysis of the regulatory potential of tagging SNPs provides evidence of the involvement of genes encoding the heat-resistant obscure (Hero) proteins in the pathogenesis of cardiovascular diseases.

Vladislav V Shilenok, Irina V Shilenok, Vladislav O Soldatov, Yuriy L Orlov, Ksenia A Kobzeva, Alexey V Deykin, Olga Yu Bushueva

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Article in Journal of integrative bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Vladislav V ShilenokLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk 305041, Russia.ORCID https://orcid.org/0000-0002-8400-6244
Irina V ShilenokLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk 305041, Russia.ORCID https://orcid.org/0000-0001-7894-8385
Vladislav O SoldatovJoint Center for Genetic Technologies and Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, Belgorod 308015, Russia.ORCID https://orcid.org/0000-0001-9706-0699
Yuriy L OrlovCenter of Biodesign and Complex Systems Modeling, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.ORCID https://orcid.org/0000-0003-0587-1609
Ksenia A KobzevaLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk 305041, Russia.ORCID https://orcid.org/0000-0002-0652-2219
Alexey V DeykinJoint Center for Genetic Technologies and Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, Belgorod 308015, Russia.ORCID https://orcid.org/0000-0001-9960-0863
Olga Yu BushuevaLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk 305041, Russia.ORCID https://orcid.org/0000-0003-3333-0623

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although multiple aspects of molecular pathology underlying cardiovascular diseases (CVDs) have been revealed, the complete picture has yet to be elucidated. In this respect, annotation of the novel links between genes and atherosclerosis is of great importance for cardiovascular medicine. Aligning with our previous research, we aimed to analyze the cardiovascular predisposition contribution of the genes encoding Hero-proteins, polypeptides with chaperone activity. Following bioinformatic sources were utilized to annotate data regarding the cardiovascular contribution of Hero-proteins and their genes: SNPinfo Web Server, The Cardiovascular Disease Knowledge Portal, GTEx Portal, HaploReg, rSNPBase, RegulomeDB, atSNP, Gene Ontology, QTLbase, and the Blood eQTL browser. Almost all analyzed genes were characterized by a very high regulatory potential of tag SNPs (except

Indexed as

Cardiovascular DiseasesComputational BiologyGenetic Predisposition to DiseasePolymorphism, Single NucleotideHumansQuantitative Trait Locicardiovascular diseasesHero (heat-resistant obscure) proteinshistone modificationsQTLtranscription factors

Identifiers

PMID40459864
PMCPMC12327200

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.